PMID- 14571510
OWN - NLM
STAT- MEDLINE
DCOM- 20040312
LR  - 20131121
IS  - 0271-3586 (Print)
IS  - 0271-3586 (Linking)
VI  - 44
IP  - 5
DP  - 2003 Nov
TI  - Utility of a routine medical surveillance program with benzene exposed workers.
PG  - 467-73
AB  - BACKGROUND: A medical surveillance program of benzene-exposed workers has to be 
      established in such a way as to observe early signs of benzene-induced cytopenia, 
      pancytopenia, or leukemia. This study evaluates the utility of routine medical 
      survey applied to benzene-exposed workers by analyzing the hematological, 
      immunological, and cytogenetic assay results. METHODS: The results of a previous 
      study of hematological, immunological, and cytogenetic assays in benzene-exposed 
      workers (up to 15 ppm) are used to discuss medical surveillance program by 
      defining the relationship between various benzene exposure concentrations and 
      toxic endpoints. RESULTS: Exposure to benzene concentration lower than 5 ppm does 
      not produce any abnormal hematological measurements. For benzene cumulative 
      exposure above 100 (ppm-years), some blood indices [mean corpuscular volume 
      (MCV), mean corpuscular hemoglobin concentration (MCHC), band neutrophils] show 
      significant differences in comparison to the control group. The incidence of 
      dicentric chromosomes was higher and the level of B-lymphocytes was lower even 
      with workers exposed to 5 ppm of benzene; correlation with exposure indicators 
      was not found. CONCLUSIONS: The results suggest that peripheral blood indices, 
      although not sensitive enough, are still the most suitable parameters in a health 
      surveillance program applied to benzene-exposed workers. B-lymphocytes could be a 
      promising indicator of the benzene-induced damage. Cytogenetic tests did not 
      prove to be suitable. Further investigation of useful screening tests for health 
      surveillance program of benzene-exposed workers is still required.
CI  - Copyright 2003 Wiley-Liss, Inc.
FAU - Bogadi-Sare, Ana
AU  - Bogadi-Sare A
AD  - Croatian Institute of Occupational Health, Division for Occupational Diseases and 
      Industrial Toxicology, Zagreb, Croatia. hzmr@hzmr.hr
FAU - Zavalic, Marija
AU  - Zavalic M
FAU - Turk, Rajka
AU  - Turk R
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Ind Med
JT  - American journal of industrial medicine
JID - 8101110
RN  - J64922108F (Benzene)
SB  - IM
MH  - Adult
MH  - Benzene/*adverse effects
MH  - Female
MH  - Hematologic Diseases/*diagnosis/etiology
MH  - Humans
MH  - Industry
MH  - Mass Screening/*methods
MH  - Middle Aged
MH  - Occupational Diseases/*diagnosis/etiology
MH  - Occupational Health
MH  - Population Surveillance/*methods
MH  - Shoes
EDAT- 2003/10/23 05:00
MHDA- 2004/03/16 05:00
CRDT- 2003/10/23 05:00
PHST- 2003/10/23 05:00 [pubmed]
PHST- 2004/03/16 05:00 [medline]
PHST- 2003/10/23 05:00 [entrez]
AID - 10.1002/ajim.10296 [doi]
PST - ppublish
SO  - Am J Ind Med. 2003 Nov;44(5):467-73. doi: 10.1002/ajim.10296.