PMID- 14571756
OWN - NLM
STAT- MEDLINE
DCOM- 20040224
LR  - 20111117
IS  - 0172-6390 (Print)
IS  - 0172-6390 (Linking)
VI  - 50
IP  - 53
DP  - 2003 Sep-Oct
TI  - The incidence of HLA DRB1*0103 in ulcerative colitis patients in north-eastern 
      Poland.
PG  - 1436-8
AB  - BACKGROUND/AIMS: Susceptibility to inflammatory bowel disease is partially 
      genetically determined and the HLA (human leukocyte antigen) alloantigens and 
      genes located in the HLA region have been studied over the course of many years 
      as the candidate genes responsible for ulcerative colitis. Improvements in 
      molecular genotyping have allowed disease association with HLA to be narrowed 
      down to specific subtypes. For class II antigens, increasing phenotype frequency 
      of DRB1*0103, DRB1*1502 is observed and positive correlation to disease 
      susceptibility is proposed. We investigated the incidence of HLA DRB1*0103 in 
      ulcerative colitis patients in North-Eastern Poland and possible association with 
      overall disease susceptibility and clinical course of the disease. METHODOLOGY: 
      41 patients and 45 healthy control blood donors were included in this study. All 
      subjects were Polish. RESULTS: The incidence of HLA DRB1*0103 was low (2.44%), 
      but was associated with fulminant course of the disease (pancolitis with 
      megacolon toxicum). None of the ethnically matched healthy control blood donors 
      possessed the HLA DRB1*0103 allele (0.00%). CONCLUSIONS: The results gained in 
      the presented study confirm, that in the Polish population HLA DRB1*0103 allele 
      is uncommon and it would not be a useful marker of disease susceptibility.
FAU - Puzanowska, B
AU  - Puzanowska B
AD  - Department of Infectious Diseases Medical University of Bialystok, 15-540 
      Bialystok, Zurawia 14, Poland. doctors@priv.onet.pl
FAU - Prokopowicz, D
AU  - Prokopowicz D
FAU - Ziarko, S
AU  - Ziarko S
FAU - Radziwon, P
AU  - Radziwon P
FAU - Lapinski, T W
AU  - Lapinski TW
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Hepatogastroenterology
JT  - Hepato-gastroenterology
JID - 8007849
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adult
MH  - Colitis, Ulcerative/*genetics
MH  - Female
MH  - Genetic Predisposition to Disease/epidemiology
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - Male
MH  - Poland
MH  - Seroepidemiologic Studies
EDAT- 2003/10/24 05:00
MHDA- 2004/02/26 05:00
CRDT- 2003/10/24 05:00
PHST- 2003/10/24 05:00 [pubmed]
PHST- 2004/02/26 05:00 [medline]
PHST- 2003/10/24 05:00 [entrez]
PST - ppublish
SO  - Hepatogastroenterology. 2003 Sep-Oct;50(53):1436-8.