PMID- 14572581
OWN - NLM
STAT- MEDLINE
DCOM- 20031126
LR  - 20071114
IS  - 0002-9270 (Print)
IS  - 0002-9270 (Linking)
VI  - 98
IP  - 10
DP  - 2003 Oct
TI  - Hepatitis B vaccine nonresponse and celiac disease.
PG  - 2289-92
AB  - OBJECTIVES: There is a genetic predisposition to hepatitis B vaccine nonresponse. 
      The link between human leukocyte antigen (HLA) genotype and ineffective 
      development of immunity to the hepatitis B vaccine has been characterized in 
      multiple studies. Celiac disease has a strong association with a particular HLA 
      genotype of DQ2; interestingly, this HLA genotype is seen in association with 
      nonresponders to the hepatitis B vaccine. We report a disproportionate number of 
      patients with celiac disease who are nonresponders to the hepatitis B vaccine 
      series. METHODS: We reviewed the hepatitis B vaccine records, serological tests 
      for anti-hepatitis B surface antigen antibody (anti-HBs), and HLA genotypes of 
      celiac disease patients identified as nonresponders to hepatitis B vaccine. 
      Subjects were identified from a database of patients diagnosed with celiac 
      disease at our institution or referred to our center for evaluation and 
      management of celiac disease between November, 2000, and October, 2002. RESULTS: 
      A total of 23 subjects were reviewed. All had a clinical and pathological 
      diagnosis of celiac disease. All subjects reported receiving the full series of 
      hepatitis B vaccinations. Of the subjects, 19 had testing for hepatitis B vaccine 
      response. Of these 19 subjects, 13 did not achieve long-term immunity as seen by 
      the negative qualitative or quantitative anti-HBs antibody titer. All tested 
      subjects were either homozygous or heterozygous for DQ2. CONCLUSIONS: We 
      postulate that celiac disease patients may have a significant predisposition to 
      hepatitis B vaccine nonresponse. Both celiac disease and hepatitis B vaccine 
      nonresponse is genetically mediated. Celiac disease patients may have a failure 
      of induction of humoral immune response needed for development of long term 
      immunity; the mechanism for this is unclear.
FAU - Noh, Kyung W
AU  - Noh KW
AD  - Department of Internal Medicine, Mayo Vaccine Research Group, and Division of 
      Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota 55905, USA.
FAU - Poland, Gregory A
AU  - Poland GA
FAU - Murray, Joseph A
AU  - Murray JA
LA  - eng
GR  - DK 57982/DK/NIDDK NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am J Gastroenterol
JT  - The American journal of gastroenterology
JID - 0421030
RN  - 0 (HLA Antigens)
RN  - 0 (Hepatitis B Surface Antigens)
RN  - 0 (Hepatitis B Vaccines)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Celiac Disease/*diagnosis/epidemiology/genetics
MH  - Female
MH  - Follow-Up Studies
MH  - HLA Antigens/*genetics/immunology
MH  - Hepatitis B/epidemiology/*immunology/prevention & control
MH  - Hepatitis B Surface Antigens/analysis
MH  - Hepatitis B Vaccines/*administration & dosage/immunology
MH  - Humans
MH  - Immunity/*physiology
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - Phenotype
MH  - Retrospective Studies
MH  - Risk Assessment
MH  - Sampling Studies
EDAT- 2003/10/24 05:00
MHDA- 2003/12/03 05:00
CRDT- 2003/10/24 05:00
PHST- 2003/10/24 05:00 [pubmed]
PHST- 2003/12/03 05:00 [medline]
PHST- 2003/10/24 05:00 [entrez]
AID - S000292700300707X [pii]
AID - 10.1111/j.1572-0241.2003.07701.x [doi]
PST - ppublish
SO  - Am J Gastroenterol. 2003 Oct;98(10):2289-92. doi: 
      10.1111/j.1572-0241.2003.07701.x.