PMID- 14573320
OWN - NLM
STAT- MEDLINE
DCOM- 20031121
LR  - 20190815
IS  - 0006-3223 (Print)
IS  - 0006-3223 (Linking)
VI  - 54
IP  - 9
DP  - 2003 Nov 1
TI  - Polymorphisms in the N-methyl-D-aspartate receptor 1 and 2B subunits are 
      associated with alcoholism-related traits.
PG  - 922-8
AB  - BACKGROUND: This study examined the hypothesis that allelic variants of the 
      ionotropic glutamatergic N-methyl-D-aspartate receptor (NMDAR) are associated 
      with vulnerability to alcoholism and some related traits. METHODS: We 
      investigated the silent G2108A and C2664T polymorphisms of the NMDAR1 and the 
      NMDAR2B genes, respectively. The case control study included 367 alcoholic and 
      335 control subjects of German origin. The family-based study comprised 81 Polish 
      alcoholic patients and their parents using the transmission disequilibrium test. 
      RESULTS: The genotype frequencies of the NMDAR1 polymorphism differed 
      significantly between control and alcoholic subjects. This difference was also 
      observed in more homogenous subgroups of alcoholic subjects with vegetative 
      withdrawal syndrome and Cloninger type 1. Patients with a history of delirium 
      tremens or seizures during withdrawal showed a significantly increased prevalence 
      of the A allele. Genotyping of the NMDAR2B polymorphism revealed a significantly 
      reduced T allele in Cloninger type 2 alcoholics and in patients reporting an 
      early onset compared with control subjects. Our family-based study for NMDAR2B, 
      revealed a trend to a preferred transmission of the C allele by the fathers, and 
      families with early-onset patients contributed most to this trend. CONCLUSIONS: 
      These results suggest that variants in NMDAR genes are associated with alcoholism 
      and related traits.
FAU - Wernicke, Catrin
AU  - Wernicke C
AD  - Department of Clinical Neurobiology, University Hospital Benjamin Franklin, Free 
      University of Berlin, Berlin, Germany.
FAU - Samochowiec, Jerzy
AU  - Samochowiec J
FAU - Schmidt, Lutz G
AU  - Schmidt LG
FAU - Winterer, Georg
AU  - Winterer G
FAU - Smolka, Michael
AU  - Smolka M
FAU - Kucharska-Mazur, Jolanta
AU  - Kucharska-Mazur J
FAU - Horodnicki, Jan
AU  - Horodnicki J
FAU - Gallinat, Jurgen
AU  - Gallinat J
FAU - Rommelspacher, Hans
AU  - Rommelspacher H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Biol Psychiatry
JT  - Biological psychiatry
JID - 0213264
RN  - 0 (NMDA receptor A1)
RN  - 0 (NR2B NMDA receptor)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
SB  - IM
MH  - Adult
MH  - Alcoholism/*genetics
MH  - Alleles
MH  - Case-Control Studies
MH  - Female
MH  - Gene Frequency
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymerase Chain Reaction
MH  - *Polymorphism, Genetic
MH  - Polymorphism, Restriction Fragment Length
MH  - Receptors, N-Methyl-D-Aspartate/*genetics
EDAT- 2003/10/24 05:00
MHDA- 2003/12/03 05:00
CRDT- 2003/10/24 05:00
PHST- 2003/10/24 05:00 [pubmed]
PHST- 2003/12/03 05:00 [medline]
PHST- 2003/10/24 05:00 [entrez]
AID - S0006322303000726 [pii]
AID - 10.1016/s0006-3223(03)00072-6 [doi]
PST - ppublish
SO  - Biol Psychiatry. 2003 Nov 1;54(9):922-8. doi: 10.1016/s0006-3223(03)00072-6.