PMID- 1457364
OWN - NLM
STAT- MEDLINE
DCOM- 19930114
LR  - 20190515
IS  - 0007-0920 (Print)
IS  - 1532-1827 (Electronic)
IS  - 0007-0920 (Linking)
VI  - 66
IP  - 6
DP  - 1992 Dec
TI  - Expression of metalloproteinases and their inhibitors in primary pulmonary 
      carcinomas.
PG  - 1188-94
AB  - Nine primary pulmonary carcinomas, one metastatic carcinoma, and two malignant 
      pleural mesotheliomas have been analysed for the expression at the mRNA level of 
      metalloproteinases (MPs) and tissue inhibitors of MPs (TIMPs). In situ 
      hybridisation showed TIMP-1 and TIMP-2 transcripts predominantly over tumour 
      stroma and gelatinases evenly distributed over both stromal and tumour cells. 
      While both TIMP-1 and TIMP-2 were expressed in non-neoplastic lungs (NNL) as well 
      as in carcinomas, stromelysin 3 (ST3), 92 kDa gelatinase and interstitial 
      collagenase were expressed only by carcinomas. Expression of these MPs by 
      carcinomas was independent of histologic type and such tumour features as 
      fibrosis or necrosis. The consistent expression of ST3 by all of the carcinomas 
      examined and absence of its expression in NNL indicates that ST3 production is 
      likely associated with the malignant phenotype. However, since 92 kDa gelatinase 
      and interstitial collagenase transcripts were found in some but not all tumour 
      samples, their expression is not a uniform feature of pulmonary carcinomas. The 
      possible prognostic significance of the expression of the latter two enzymes by 
      carcinomas remains to be established.
FAU - Urbanski, S J
AU  - Urbanski SJ
AD  - Department of Pathology, University of Calgary, Alberta, Canada.
FAU - Edwards, D R
AU  - Edwards DR
FAU - Maitland, A
AU  - Maitland A
FAU - Leco, K J
AU  - Leco KJ
FAU - Watson, A
AU  - Watson A
FAU - Kossakowska, A E
AU  - Kossakowska AE
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Br J Cancer
JT  - British journal of cancer
JID - 0370635
RN  - 0 (Glycoproteins)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (RNA, Neoplasm)
RN  - 0 (Tissue Inhibitor of Metalloproteinases)
RN  - 127497-59-0 (Tissue Inhibitor of Metalloproteinase-2)
RN  - EC 3.4.23.1 (Pepsin A)
RN  - EC 3.4.24.- (Collagenases)
RN  - EC 3.4.24.- (Matrix Metalloproteinase 11)
RN  - EC 3.4.24.- (Metalloendopeptidases)
RN  - EC 3.4.24.23 (Matrix Metalloproteinase 7)
SB  - IM
MH  - Aged
MH  - Blotting, Northern
MH  - Collagenases/*analysis
MH  - Female
MH  - Glycoproteins/*analysis
MH  - Humans
MH  - Lung/*enzymology
MH  - Lung Neoplasms/*enzymology
MH  - Male
MH  - Matrix Metalloproteinase 11
MH  - Matrix Metalloproteinase 7
MH  - Metalloendopeptidases/*analysis
MH  - Middle Aged
MH  - Neoplasm Proteins/*analysis
MH  - Pepsin A/*analysis
MH  - RNA, Messenger/analysis
MH  - RNA, Neoplasm/analysis
MH  - Tissue Inhibitor of Metalloproteinase-2
MH  - Tissue Inhibitor of Metalloproteinases
PMC - PMC1978055
EDAT- 1992/12/01 00:00
MHDA- 1992/12/01 00:01
CRDT- 1992/12/01 00:00
PHST- 1992/12/01 00:00 [pubmed]
PHST- 1992/12/01 00:01 [medline]
PHST- 1992/12/01 00:00 [entrez]
AID - 10.1038/bjc.1992.434 [doi]
PST - ppublish
SO  - Br J Cancer. 1992 Dec;66(6):1188-94. doi: 10.1038/bjc.1992.434.