PMID- 14573689
OWN - NLM
STAT- MEDLINE
DCOM- 20031120
LR  - 20210526
IS  - 0019-9567 (Print)
IS  - 1098-5522 (Electronic)
IS  - 0019-9567 (Linking)
VI  - 71
IP  - 11
DP  - 2003 Nov
TI  - Mice deficient in nuclear factor of activated T-cell transcription factor c2 
      mount increased Th2 responses after infection with Nippostrongylus brasiliensis 
      and decreased Th1 responses after mycobacterial infection.
PG  - 6641-7
AB  - Infection of nuclear factor of activated T-cell transcription factor c2 
      (NFATc2)-deficient mice with the helminth Nippostrongylus brasiliensis led to a 
      distinct increase in interleukin-4 (IL-4) and IL-5 protein synthesis by lymph 
      node and spleen cells and to elevated serum immunoglobulin E (IgE) levels in 
      comparison to those seen with infected control mice. While IL-4, IL-5, and IL-13 
      mRNA expression was also enhanced in lymph node cells from the lungs of infected 
      NFATc2(-/-) mice, the number of T cells secreting Th2-type lymphokines remained 
      the same in mice infected with N. brasiliensis. In contrast, lymphocytes from 
      NFATc2-deficient mice infected with Mycobacterium bovis BCG secreted less gamma 
      interferon than lymphocytes from infected control mice. These findings indicate 
      that NFATc2 is an activator of Th1 responses and a suppressor of Th2 responses in 
      vivo.
FAU - Erb, Klaus J
AU  - Erb KJ
AD  - Department of Molecular Pathology, Institute of Pathology, University of 
      Wuerzburg, D-97080 Wuerzburg, Germany. klaus.erb@mail.uni-wuerzburg.de
FAU - Twardzik, Thomas
AU  - Twardzik T
FAU - Palmetshofer, Alois
AU  - Palmetshofer A
FAU - Wohlleben, Gisela
AU  - Wohlleben G
FAU - Tatsch, Ursula
AU  - Tatsch U
FAU - Serfling, Edgar
AU  - Serfling E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Infect Immun
JT  - Infection and immunity
JID - 0246127
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Interleukin-5)
RN  - 0 (NFATC Transcription Factors)
RN  - 0 (Nfatc2 protein, mouse)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Transcription Factors)
RN  - 207137-56-2 (Interleukin-4)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Animals
MH  - DNA-Binding Proteins/*physiology
MH  - Immunoglobulin E/blood
MH  - Interferon-gamma/biosynthesis
MH  - Interleukin-4/biosynthesis
MH  - Interleukin-5/biosynthesis
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mycobacterium bovis
MH  - NFATC Transcription Factors
MH  - *Nippostrongylus
MH  - *Nuclear Proteins
MH  - Strongylida Infections/*immunology
MH  - Th1 Cells/*immunology
MH  - Th2 Cells/*immunology
MH  - Transcription Factors/*physiology
MH  - Tuberculosis/*immunology
PMC - PMC219542
EDAT- 2003/10/24 05:00
MHDA- 2003/12/03 05:00
PMCR- 2003/11/01
CRDT- 2003/10/24 05:00
PHST- 2003/10/24 05:00 [pubmed]
PHST- 2003/12/03 05:00 [medline]
PHST- 2003/10/24 05:00 [entrez]
PHST- 2003/11/01 00:00 [pmc-release]
AID - 0096 [pii]
AID - 10.1128/IAI.71.11.6641-6647.2003 [doi]
PST - ppublish
SO  - Infect Immun. 2003 Nov;71(11):6641-7. doi: 10.1128/IAI.71.11.6641-6647.2003.