PMID- 14574807
OWN - NLM
STAT- MEDLINE
DCOM- 20040309
LR  - 20061115
IS  - 1009-3591 (Print)
IS  - 1009-3591 (Linking)
VI  - 9
IP  - 6
DP  - 2003 Sep
TI  - [Diagnostic value of complexed prostate-specific antigen for prostate cancer].
PG  - 431-3
AB  - OBJECTIVE: To assess the clinical value of serum complexed prostate-specific 
      antigen(cPSA) in the diagnosis of prostate cancer (PCa). METHODS: Serum samples 
      were obtained from 110 men with untreated benign prostatic hyperplasia (BPH) and 
      78 men with untreated PCa. The levels of cPSA, total PSA (tPSA) were determined 
      by autoimmunochemistry luminescence method. RESULTS: Both cPSA and cPSA/tPSA 
      ratio were significantly different between patients with PCa and BPH (P < 0.005), 
      especially, in men with tPSA values between 4.0-10.0 micrograms/L (the diagnostic 
      gray zone). When cPSA/tPSA > or = 0.78 was taken as the cut-off value conjugated 
      with tPSA < or = 10.0 micrograms/L, the sensitivity, specificity, negative 
      predictive value and positive predictive value were as high as 97.8%, 95.8%, 
      81.9% and 96.5%. CONCLUSIONS: With the introduction of cPSA and cPSA/tPSA ratio, 
      early diagnosis of PCa by the assessment of tPSA has been made more sensitive and 
      reliable, especially when the tPSA is within the diagnostic gray zone.
FAU - Su, Han-Wen
AU  - Su HW
AD  - Department of Clinical Laboratory Science, Renmin Hospital, Wuhan University, 
      Wuhan, Hubei 430060, China.
FAU - Li, Yan
AU  - Li Y
FAU - Xu, Pu
AU  - Xu P
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Nan Ke Xue
JT  - Zhonghua nan ke xue = National journal of andrology
JID - 101093592
RN  - EC 3.4.21.77 (Prostate-Specific Antigen)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prostate-Specific Antigen/*blood
MH  - Prostatic Hyperplasia/blood/diagnosis
MH  - Prostatic Neoplasms/blood/*diagnosis
EDAT- 2003/10/25 05:00
MHDA- 2004/03/10 05:00
CRDT- 2003/10/25 05:00
PHST- 2003/10/25 05:00 [pubmed]
PHST- 2004/03/10 05:00 [medline]
PHST- 2003/10/25 05:00 [entrez]
PST - ppublish
SO  - Zhonghua Nan Ke Xue. 2003 Sep;9(6):431-3.