PMID- 14575216
OWN - NLM
STAT- MEDLINE
DCOM- 20031120
LR  - 20220317
IS  - 0019-5847 (Print)
IS  - 0019-5847 (Linking)
VI  - 101
IP  - 5
DP  - 2003 May
TI  - A study on the serum levels of interleukin-1beta in bronchial asthma.
PG  - 282, 284, 286 passim
AB  - Mononuclear phagocytes can be activated through an immunoglobulin E (IgE)- 
      specific mechanism to release pro-inflammatory cytokine like interleukin-1beta 
      (IL-1beta). The present study was conducted to show the inter-relationship 
      between these two parameters in the serum of asthmatic patients. The study 
      included 30 patients of asthma and 10 as control. Out of these 30 cases, 20 
      patients had stable and 10 had acute asthma. Of the 20 stable patients, 9 were 
      allergic and 11 were non-allergic to either of the 12 allergens used for skin 
      prick test. Serum IgE and IL-1beta levels were measured by enzyme linked 
      immunosorbent assay (ELISA). Total serum IgE levels increased significantly (p < 
      0.05) in asthma [200.5 +/- 30.91 IU/ml, mean +/- standard error of mean (SEM)] in 
      comparison with the controls (18.15 +/- 4.35 IU/ml). Serum IL-1beta level was 
      higher in allergic (1.94 +/- 0.63 pg/ml) than in non-allergic patients (0.64 +/- 
      0.21 pg/ml) but it was not statistically significant (p > 0.05). The study 
      suggests involvement of IgE and IL-1beta in the pathophysiology of allergic 
      asthmatic condition. Further studies are required to delineate the inflammatory 
      pathway in asthma and determine stages at which therapeutic interventions can be 
      done.
FAU - Thomas, Sherin S
AU  - Thomas SS
AD  - Maulana Azad Medical College, New Delhi 110002.
FAU - Chhabra, Sunil K
AU  - Chhabra SK
LA  - eng
PT  - Journal Article
PL  - India
TA  - J Indian Med Assoc
JT  - Journal of the Indian Medical Association
JID - 7505608
RN  - 0 (Interleukin-1)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Acute Disease
MH  - Adult
MH  - Asthma/*blood/complications
MH  - Female
MH  - Humans
MH  - Hypersensitivity/*blood/complications
MH  - Immunoglobulin E/blood
MH  - Interleukin-1/*blood
MH  - Male
MH  - Middle Aged
EDAT- 2003/10/25 05:00
MHDA- 2003/12/03 05:00
CRDT- 2003/10/25 05:00
PHST- 2003/10/25 05:00 [pubmed]
PHST- 2003/12/03 05:00 [medline]
PHST- 2003/10/25 05:00 [entrez]
PST - ppublish
SO  - J Indian Med Assoc. 2003 May;101(5):282, 284, 286 passim.