PMID- 14575794
OWN - NLM
STAT- MEDLINE
DCOM- 20040617
LR  - 20190624
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 478
IP  - 2-3
DP  - 2003 Oct 8
TI  - Effect of morphine, naloxone and histamine system on water intake in adult male 
      rats.
PG  - 105-10
AB  - The present study investigated the interaction between histamine and opioid 
      systems on water intake in adult male rats. Intracerebroventricular (i.c.v.) 
      injections were carried out in all experiments. Water intake was measured 1 h 
      after drug injections. Administration of histamine (40-80 microg/rat) and 
      naloxone (0.5-1 microg/rat) increased, while morphine (2.5 microg/rat), 
      pyrilamine (25-50 microg/rat), the histamine H1 receptor antagonist, and 
      ranitidine (10-20 microg/rat), the histamine H2 receptor antagonist, decreased 
      water intake in isolated rats. Blockade of histamine H1 and H2 receptors 
      attenuated the histamine-induced response. Pyrilamine, but not ranitidine, 
      increased the inhibitory effect induced by morphine. Also, pharmacological 
      blockade of histamine H1 and H2 receptors decreased the naloxone-induced effect 
      on water intake. It is concluded that the histaminergic system may have a close 
      interaction with morphine and naloxone on drinking behavior.
FAU - Eidi, Maryam
AU  - Eidi M
AD  - Department of Biology, Varamin Unit, Islamic Azad University, Varamin, Iran.
FAU - Oryan, Shahrbanoo
AU  - Oryan S
FAU - Eidi, Akram
AU  - Eidi A
FAU - Sepehrara, Leili
AU  - Sepehrara L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Analgesics, Opioid)
RN  - 0 (Histamine H1 Antagonists)
RN  - 0 (Histamine H2 Antagonists)
RN  - 0 (Narcotic Antagonists)
RN  - 0 (Receptors, Histamine H1)
RN  - 0 (Receptors, Histamine H2)
RN  - 36B82AMQ7N (Naloxone)
RN  - 76I7G6D29C (Morphine)
RN  - 820484N8I3 (Histamine)
SB  - IM
MH  - Analgesics, Opioid/*pharmacology
MH  - Animals
MH  - Drinking/*drug effects
MH  - Histamine/administration & dosage/pharmacology/*physiology
MH  - Histamine H1 Antagonists/pharmacology
MH  - Histamine H2 Antagonists/pharmacology
MH  - Injections, Intraventricular
MH  - Male
MH  - Morphine/*pharmacology
MH  - Naloxone/*pharmacology
MH  - Narcotic Antagonists/*pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Receptors, Histamine H1/drug effects
MH  - Receptors, Histamine H2/drug effects
EDAT- 2003/10/25 05:00
MHDA- 2004/06/18 05:00
CRDT- 2003/10/25 05:00
PHST- 2003/10/25 05:00 [pubmed]
PHST- 2004/06/18 05:00 [medline]
PHST- 2003/10/25 05:00 [entrez]
AID - S0014299903021265 [pii]
AID - 10.1016/j.ejphar.2003.07.001 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 2003 Oct 8;478(2-3):105-10. doi: 10.1016/j.ejphar.2003.07.001.