PMID- 14575905
OWN - NLM
STAT- MEDLINE
DCOM- 20040122
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 991
IP  - 1-2
DP  - 2003 Nov 21
TI  - In vivo insular cortex LTP induced by brain-derived neurotrophic factor.
PG  - 274-9
AB  - Recent studies suggest that brain-derived neurotrophic factor (BDNF) plays a 
      critical role in long-term synaptic plasticity in the adult brain. Previous 
      studies on the insular cortex (IC), a region of the temporal cortex implicated in 
      the acquisition and storage of different aversive learning tasks, have 
      demonstrated that tetanic stimulation of the basolateral nucleus of the amygdala 
      (Bla) induces an N-methyl-D-aspartate (NMDA)-dependent form of long-term 
      potentiation (LTP) in the IC of adult rats in vivo. Here, we show that acute 
      intracortical microinfusion of BDNF induces a lasting potentiation of synaptic 
      efficacy in the Bla-IC projection of anesthetized adult rats. This constitutes an 
      in vivo demonstration of neurotrophin-induced potentiation of synaptic 
      transmission in the neocortex. These findings support the concept that BDNF could 
      be a synaptic messenger involved in activity-dependent synaptic plasticity.
FAU - Escobar, Martha L
AU  - Escobar ML
AD  - Division de Investigacion y Estudios de Posgrado, Facultad de Psicologia, 
      Universidad Nacional Autonoma de Mexico, Cub 4 y 5, 1er Piso, Edif. D, C P 04510 
      Mexico D.F., Mexico. mescobar@correo.unam.mx
FAU - Figueroa-Guzman, Yazmin
AU  - Figueroa-Guzman Y
FAU - Gomez-Palacio-Schjetnan, Andrea
AU  - Gomez-Palacio-Schjetnan A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/administration & dosage/*pharmacology
MH  - Excitatory Postsynaptic Potentials/drug effects/physiology
MH  - Injections, Intraventricular
MH  - Long-Term Potentiation/drug effects/physiology
MH  - Male
MH  - Neuronal Plasticity/drug effects/*physiology
MH  - Rats
MH  - Rats, Wistar
MH  - Synaptic Transmission/*drug effects/physiology
MH  - Temporal Lobe/*drug effects/physiology
EDAT- 2003/10/25 05:00
MHDA- 2004/01/24 05:00
CRDT- 2003/10/25 05:00
PHST- 2003/10/25 05:00 [pubmed]
PHST- 2004/01/24 05:00 [medline]
PHST- 2003/10/25 05:00 [entrez]
AID - S0006899303035595 [pii]
AID - 10.1016/j.brainres.2003.08.015 [doi]
PST - ppublish
SO  - Brain Res. 2003 Nov 21;991(1-2):274-9. doi: 10.1016/j.brainres.2003.08.015.