PMID- 14575907
OWN - NLM
STAT- MEDLINE
DCOM- 20040212
LR  - 20190827
IS  - 0165-5728 (Print)
IS  - 0165-5728 (Linking)
VI  - 143
IP  - 1-2
DP  - 2003 Oct
TI  - The genetic epidemiology of multiple sclerosis.
PG  - 7-12
AB  - Multiple sclerosis (MS) is a debilitating immunological and neurodegenerative 
      disorder. Epidemiological studies have provided overwhelming evidence of complex 
      genetic susceptibility to MS. However, with the exception of the human leukocyte 
      antigen (HLA) locus, genetic studies have failed to consistently identify 
      significant linkage or association with genes that modulate MS disease 
      expression. Numerous functional candidate gene studies, linkage genomic screens, 
      and locational candidate gene studies have been performed in an attempt to 
      identify additional loci. However, these methods have demonstrated insufficient 
      power to consistently identify genes or epigenetic factors for MS. More current 
      approaches integrate information from a variety of sources (e.g. consistent 
      linkage data, gene expression profiling, and functional characterization studies) 
      and utilize high throughput methods (e.g. genotyping high density markers, 
      utilizing pooling schemes and performing new statistical analyses) in an attempt 
      to overcome power issues. The following article presents a review of MS genetics 
      research and a brief overview of methods that are currently being developed and 
      utilized for fine localization of MS loci, such as the method employed in the 
      Genetic Analysis of Multiple sclerosis in EuropeanS (GAMES) study that is 
      presented elsewhere in this journal. It is the hope of researchers that these 
      methods will lead to the identification of susceptibility genes for MS that aid 
      in elucidating pathogenic mechanisms and potential therapeutic strategies for 
      this debilitating disease.
FAU - Kenealy, Shannon J
AU  - Kenealy SJ
AD  - Department of Molecular Physiology and Biophysics, Program in Human Genetics, 519 
      Light Hall, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
FAU - Pericak-Vance, Margaret A
AU  - Pericak-Vance MA
FAU - Haines, Jonathan L
AU  - Haines JL
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
SB  - IM
MH  - Genetic Testing/methods
MH  - Genetics, Population
MH  - Humans
MH  - International Cooperation
MH  - *Molecular Epidemiology/methods
MH  - Multicenter Studies as Topic
MH  - Multiple Sclerosis/*epidemiology/*genetics/immunology/pathology
MH  - Prevalence
RF  - 56
EDAT- 2003/10/25 05:00
MHDA- 2004/02/13 05:00
CRDT- 2003/10/25 05:00
PHST- 2003/10/25 05:00 [pubmed]
PHST- 2004/02/13 05:00 [medline]
PHST- 2003/10/25 05:00 [entrez]
AID - S0165572803003035 [pii]
AID - 10.1016/j.jneuroim.2003.08.005 [doi]
PST - ppublish
SO  - J Neuroimmunol. 2003 Oct;143(1-2):7-12. doi: 10.1016/j.jneuroim.2003.08.005.