PMID- 1457809
OWN - NLM
STAT- MEDLINE
DCOM- 19930108
LR  - 20191021
IS  - 1042-5179 (Print)
IS  - 1026-7913 (Linking)
VI  - 3
IP  - 1
DP  - 1992
TI  - Gene sequences of chicken BDNF and NT-3.
PG  - 49-54
AB  - The respective amino acid sequences of mature brain-derived neurotrophic factor 
      (BDNF) and of mature neurotrophin-3 (NT-3) are identical among mammals, making 
      these among the structurally conserved factors known. Here we show that only a 
      single conservative amino acid substitution distinguishes the chicken mature NT-3 
      protein from its mammalian counterpart. Chicken mature BDNF shows slightly more 
      variation, differing from mammalian BDNF at several positions. We also note the 
      presence of amino acid sequence motifs in the precursor protein sequences of 
      chicken BDNF and NT-3 that are universally conserved among all known mammalian 
      neurotrophin precursors and have been demonstrated to play a crucial role in 
      promoting correct processing of the pro-proteins.
FAU - Maisonpierre, P C
AU  - Maisonpierre PC
AD  - Regeneron Pharmaceuticals, Inc., Tarrytown, N.Y. 10591-6707.
FAU - Belluscio, L
AU  - Belluscio L
FAU - Conover, J C
AU  - Conover JC
FAU - Yancopoulos, G D
AU  - Yancopoulos GD
LA  - eng
SI  - GENBANK/M83377
SI  - GENBANK/M83378
SI  - GENBANK/M84799
SI  - GENBANK/S44931
SI  - GENBANK/S44934
SI  - GENBANK/X62255
SI  - GENBANK/X62256
SI  - GENBANK/X62257
SI  - GENBANK/X62258
SI  - GENBANK/X62259
PT  - Journal Article
PL  - England
TA  - DNA Seq
JT  - DNA sequence : the journal of DNA sequencing and mapping
JID - 9107800
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Neurotrophin 3)
RN  - 9007-49-2 (DNA)
SB  - IM
GS  - BDNF
GS  - NT-3
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Brain-Derived Neurotrophic Factor
MH  - Chickens
MH  - DNA
MH  - Molecular Sequence Data
MH  - Nerve Growth Factors/*genetics
MH  - Nerve Tissue Proteins/*genetics
MH  - Neurotrophin 3
MH  - Sequence Homology, Amino Acid
EDAT- 1992/01/01 00:00
MHDA- 1992/01/01 00:01
CRDT- 1992/01/01 00:00
PHST- 1992/01/01 00:00 [pubmed]
PHST- 1992/01/01 00:01 [medline]
PHST- 1992/01/01 00:00 [entrez]
AID - 10.3109/10425179209039695 [doi]
PST - ppublish
SO  - DNA Seq. 1992;3(1):49-54. doi: 10.3109/10425179209039695.