PMID- 14578759
OWN - NLM
STAT- MEDLINE
DCOM- 20031209
LR  - 20171116
IS  - 0041-1337 (Print)
IS  - 0041-1337 (Linking)
VI  - 76
IP  - 8
DP  - 2003 Oct 27
TI  - Strong human leukocyte antigen matching effect in nonsensitized kidney recipients 
      with high pretransplant soluble CD30.
PG  - 1231-2
AB  - The influence of human leukocyte antigen (HLA) matching on graft survival is 
      greater in patients with preformed lymphocytotoxic antibodies than in 
      nonsensitized patients. Pretransplant serum soluble CD30 (sCD30) affects graft 
      outcome independently of presensitization status. The impact of HLA compatibility 
      on kidney transplant survival was analyzed in 3980 nonsensitized first cadaveric 
      kidney recipients in relation to the pretransplant serum sCD30 content. Although 
      HLA compatibility influenced graft outcome only marginally in nonsensitized 
      recipients with low sCD30 (at 3 years: P=0.0095; at 5 years: P=0.1033), a strong 
      HLA matching effect was observed in nonsensitized recipients with high sCD30 (at 
      3 years: P<0.0001; at 5 years: P=0.0001). Nonsensitized patients with high 
      pretransplant sCD30 benefit from an HLA well-matched kidney. Patients should be 
      tested for sCD30 while on the waiting list for a kidney transplant, and HLA 
      well-matched kidneys should be allocated to patients with high sCD30.
FAU - Susal, Caner
AU  - Susal C
AD  - Department of Transplantation Immunology, University of Heidelberg, Heidelberg, 
      Germany. caner.suesal@med.uni-heidelberg.de
FAU - Pelzl, Steffen
AU  - Pelzl S
FAU - Opelz, Gerhard
AU  - Opelz G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Transplantation
JT  - Transplantation
JID - 0132144
RN  - 0 (Ki-1 Antigen)
SB  - IM
MH  - Cadaver
MH  - Graft Survival
MH  - *Histocompatibility
MH  - Histocompatibility Testing
MH  - Humans
MH  - Immunization
MH  - Ki-1 Antigen/*blood/chemistry
MH  - *Kidney Transplantation
MH  - Preoperative Care
MH  - Solubility
EDAT- 2003/10/28 05:00
MHDA- 2003/12/10 05:00
CRDT- 2003/10/28 05:00
PHST- 2003/10/28 05:00 [pubmed]
PHST- 2003/12/10 05:00 [medline]
PHST- 2003/10/28 05:00 [entrez]
AID - 10.1097/01.TP.0000085286.93715.E0 [doi]
PST - ppublish
SO  - Transplantation. 2003 Oct 27;76(8):1231-2. doi: 
      10.1097/01.TP.0000085286.93715.E0.