PMID- 1457952
OWN - NLM
STAT- MEDLINE
DCOM- 19930111
LR  - 20131121
IS  - 1058-2916 (Print)
IS  - 1058-2916 (Linking)
VI  - 38
IP  - 3
DP  - 1992 Jul-Sep
TI  - Solute clearance in continuous venovenous hemodialysis. A comparison of 
      cuprophane, polyacrylonitrile, and polysulfone membranes.
PG  - M697-701
AB  - Critically ill patients with ARF and MOSF were treated with continuous venovenous 
      hemodialysis (CVVHD). The BSM 22 delivery system (CGH Medical, Denver, CO) and 
      four different dialyzer membranes were used. Vascular access was achieved with a 
      dual lumen catheter placed percutaneously into a large vein. Heparin was used for 
      anticoagulation, and commercially available peritoneal dialysis fluid was used as 
      dialysate. At a fixed blood flow rate of 100 ml/min, the dialysate inflow and 
      outflow rates were regulated to control azotemia and fluid balance. Blood side 
      and dialysate side clearances for urea nitrogen, creatinine, bicarbonate, and 
      lactate were measured. All dialyzer membranes studied provided high urea nitrogen 
      clearance approximating dialysate outflow rate and resulting in excellent control 
      of azotemia. Some of the dialyzer membranes also had high creatinine and 
      bicarbonate clearances. Bicarbonate loss was balanced by lactate uptake with all 
      dialyzers. It is concluded that CVVHD is an efficient and safe therapy for acute 
      renal failure, capable of maintaining nitrogen balance in patients with protein 
      catabolic rates up to 2 g/kg/day. Urea nitrogen clearance is dependent upon 
      dialysate outflow rate rather than the dialyzer membrane type or dialyzer flow 
      geometry, and may prove to be the modality of choice for therapy of acute renal 
      failure in unstable patients with MOSF.
FAU - Ifediora, O C
AU  - Ifediora OC
AD  - Division of Nephrology, Lankenau Hospital, Wynnewood, Pennsylvania.
FAU - Teehan, B P
AU  - Teehan BP
FAU - Sigler, M H
AU  - Sigler MH
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - ASAIO J
JT  - ASAIO journal (American Society for Artificial Internal Organs : 1992)
JID - 9204109
RN  - 0 (Acrylic Resins)
RN  - 0 (Bicarbonates)
RN  - 0 (Lactates)
RN  - 0 (Membranes, Artificial)
RN  - 0 (Polymers)
RN  - 0 (Sulfones)
RN  - 25014-41-9 (polyacrylonitrile)
RN  - 25135-51-7 (polysulfone P 1700)
RN  - 33X04XA5AT (Lactic Acid)
RN  - 8W8T17847W (Urea)
RN  - 9004-34-6 (Cellulose)
RN  - 9050-09-3 (cuprammonium cellulose)
RN  - MU72812GK0 (Creatine)
SB  - IM
MH  - Acrylic Resins
MH  - Acute Kidney Injury/complications/metabolism/therapy
MH  - Aged
MH  - Aged, 80 and over
MH  - Bicarbonates/metabolism
MH  - Cellulose/analogs & derivatives
MH  - Creatine/metabolism
MH  - Female
MH  - Humans
MH  - *Kidneys, Artificial
MH  - Kinetics
MH  - Lactates/metabolism
MH  - Lactic Acid
MH  - Male
MH  - Membranes, Artificial
MH  - Multiple Organ Failure/complications/metabolism/therapy
MH  - Polymers
MH  - Renal Dialysis/*methods
MH  - Sulfones
MH  - Urea/metabolism
EDAT- 1992/07/01 00:00
MHDA- 1992/07/01 00:01
CRDT- 1992/07/01 00:00
PHST- 1992/07/01 00:00 [pubmed]
PHST- 1992/07/01 00:01 [medline]
PHST- 1992/07/01 00:00 [entrez]
PST - ppublish
SO  - ASAIO J. 1992 Jul-Sep;38(3):M697-701.