PMID- 14579786
OWN - NLM
STAT- MEDLINE
DCOM- 20031212
LR  - 20061115
IS  - 0161-6412 (Print)
IS  - 0161-6412 (Linking)
VI  - 25
IP  - 7
DP  - 2003 Oct
TI  - Neurotrophic effect of hepatocyte growth factor on neonatal facial motor neurons.
PG  - 701-7
AB  - The neurotrophic effect of hepatocyte growth factor (HGF) on axotomized facial 
      motor neurons was examined after local application of HGF to the proximal facial 
      nerve stump of the neonatal rat on post-natal day one (P1). Motor neuron survival 
      was expressed as the neuronal cell count on the injured side as a percentage of 
      that on the noninjured side. Motor neuron survival of the control group was 76% 
      on P3, 54% on P5 and 23% on P8, that of the HGF-treated group 78% on P3, 69% on 
      P5 and 31% on P8, and that of the brain-derived neurotrophic factor 
      (BDNF)-treated group 91% on P5 and 45% on P8. The motor neuron survival rates 
      were then adjusted by deducting the facial motor neurons corresponding to the 
      uninjured retroauricular branch (20%) of the facial nerve. The adjusted values 
      were 70% (P3), 42% (P5) and 4% (P8) for the control group, 72% (P3), 61% (P5) and 
      14% (P8) for the HGF-treated group, and 88% (P5) and 32% (P8) for the 
      BDNF-treated group. These findings demonstrate that HGF has a neuroprotective 
      effect on injured facial motor neurons and suggest that HGF has neurotrophic 
      properties distinct from those of BDNF.
FAU - Koyama, J
AU  - Koyama J
AD  - Department of Neurosurgery, Shinshu University School of Medicine, 3-1-1 Asahi, 
      Matsumoto 390-8621, Japan.
FAU - Yokouchi, K
AU  - Yokouchi K
FAU - Fukushima, N
AU  - Fukushima N
FAU - Kawagishi, K
AU  - Kawagishi K
FAU - Higashiyama, F
AU  - Higashiyama F
FAU - Moriizumi, T
AU  - Moriizumi T
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Neurol Res
JT  - Neurological research
JID - 7905298
RN  - 0 (Nerve Growth Factors)
RN  - 67256-21-7 (Hepatocyte Growth Factor)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Cell Survival/drug effects/physiology
MH  - Facial Nerve/*drug effects/pathology/physiology
MH  - Hepatocyte Growth Factor/*pharmacology
MH  - Motor Neurons/*drug effects/pathology/physiology
MH  - Nerve Growth Factors/pharmacology
MH  - Rats
MH  - Rats, Wistar
EDAT- 2003/10/29 05:00
MHDA- 2003/12/13 05:00
CRDT- 2003/10/29 05:00
PHST- 2003/10/29 05:00 [pubmed]
PHST- 2003/12/13 05:00 [medline]
PHST- 2003/10/29 05:00 [entrez]
AID - 10.1179/016164103101202192 [doi]
PST - ppublish
SO  - Neurol Res. 2003 Oct;25(7):701-7. doi: 10.1179/016164103101202192.