PMID- 14580766
OWN - NLM
STAT- MEDLINE
DCOM- 20031203
LR  - 20220321
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 147
IP  - 1
DP  - 2003 Nov
TI  - Genesis of variant Philadelphia chromosome translocations in chronic myelocytic 
      leukemia.
PG  - 18-22
AB  - The Philadelphia (Ph) chromosome is found in more than 90% of chronic myelocytic 
      leukemia (CML) patients. In most cases, it results from the reciprocal 
      t(9;22)(q34;q11), with the ABL proto-oncogene from 9q34 fused to the breakpoint 
      cluster region (BCR) locus on 22q11. In 5%-10% of patients with CML, the Ph 
      chromosome originates from variant translocations, involving various breakpoints 
      in addition to 9q34 and 22q11. In our investigation, three CML cases with complex 
      Ph translocations have been analyzed by G-banding and fluorescence in situ 
      hybridization (FISH). FISH with breakpoint-spanning probes for the BCR and ABL 
      genes revealed information about the genesis of complex Ph translocations. The 
      occurrence of one fusion signal indicates a one-step mechanism (case 1). Two 
      fusion signals indicate a two-step mechanism (case 2). Lack of signals indicates 
      deletions of parts of the BCR and ABL genes or of adjacent regions (case 3).
FAU - Naumann, Sabine
AU  - Naumann S
AD  - Third Medical Clinic, Department of Hematology, Johannes Gutenberg University of 
      Mainz, Germany.
FAU - Decker, Hans-Jochen
AU  - Decker HJ
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - 0 (Genetic Markers)
RN  - 0 (MAS1 protein, human)
RN  - 0 (Proto-Oncogene Mas)
SB  - IM
MH  - Adult
MH  - Chromosome Banding
MH  - Chromosomes, Human, Pair 11
MH  - Chromosomes, Human, Pair 22
MH  - Chromosomes, Human, Pair 9
MH  - Female
MH  - Genetic Markers
MH  - *Genetic Variation
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Leukemia, Myelogenous, Chronic, BCR-ABL Positive/*genetics
MH  - Male
MH  - Middle Aged
MH  - *Philadelphia Chromosome
MH  - Proto-Oncogene Mas
MH  - *Translocation, Genetic
EDAT- 2003/10/29 05:00
MHDA- 2003/12/04 05:00
CRDT- 2003/10/29 05:00
PHST- 2003/10/29 05:00 [pubmed]
PHST- 2003/12/04 05:00 [medline]
PHST- 2003/10/29 05:00 [entrez]
AID - S0165460803001286 [pii]
AID - 10.1016/s0165-4608(03)00128-6 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2003 Nov;147(1):18-22. doi: 
      10.1016/s0165-4608(03)00128-6.