PMID- 14581666
OWN - NLM
STAT- MEDLINE
DCOM- 20040924
LR  - 20220408
IS  - 1526-632X (Electronic)
IS  - 0028-3878 (Linking)
VI  - 61
IP  - 8
DP  - 2003 Oct 28
TI  - Assessment of acute morbidity and mortality in nonconvulsive status epilepticus.
PG  - 1066-73
AB  - OBJECTIVE: S: The natural history of nonconvulsive status epilepticus (NCSE) is 
      not well defined, especially mortality and morbidity. The authors hypothesized 
      that the mortality of NCSE is higher when NCSE is due to acute medical causes 
      (systemic or neurologic) or associated with severe impairment of mental status or 
      with acute complications, and lower when associated with generalized spike-wave 
      (SW) discharges on EEG. METHODS: The authors retrospectively identified 100 
      consecutive patients with NCSE from an EEG database. Data were collected from 
      systematic review of medical records and actual EEG tracings. Specific etiologies 
      were divided into three groups: acute medical, epilepsy, and cryptogenic. 
      RESULTS: Of the 100 patients, 18 died. Fourteen of 52 patients in the acute 
      medical group died, 1 of 31 in the epilepsy group died, and 3 of 17 in the 
      cryptogenic group died. Mental status impairment was severe in 33, complications 
      occurred in 39, and generalized SW discharges occurred in 36. Mortality rates 
      were higher in patients 1) in the acute medical group (27%) vs the epilepsy (3%) 
      and the cryptogenic (18%) groups (p < 0.02), 2) with severe mental status 
      impairment (39%) compared to those with mild impairment (7%, p < 0.001), and 3) 
      with acute complications (36%) when compared with those without complications 
      (7%, p < 0.0002). The presence of generalized SW discharges on EEG did not 
      correlate with mortality. Mental status impairment and etiology were 
      independently associated with mortality (p < 0.001). CONCLUSION: NCSE is 
      associated with substantial mortality. Mortality is associated with an acute 
      medical cause as the underlying etiology, severe mental status impairment, and 
      development of acute complications, but not the type of EEG discharge.
FAU - Shneker, Bassel F
AU  - Shneker BF
AD  - University of Virginia Department of Neurology, Comprehensive Epilepsy Program, 
      Charlottesville 22908, USA.
FAU - Fountain, Nathan B
AU  - Fountain NB
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Neurology
JT  - Neurology
JID - 0401060
RN  - 12794-10-4 (Benzodiazepines)
SB  - IM
CIN - Neurology. 2003 Oct 28;61(8):1035-6. PMID: 14581659
MH  - Adult
MH  - Aged
MH  - Benzodiazepines
MH  - Child
MH  - Cognition Disorders/epidemiology
MH  - Comorbidity
MH  - Databases, Factual/statistics & numerical data
MH  - Electroencephalography/statistics & numerical data
MH  - Humans
MH  - Incidence
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Status Epilepticus/diagnosis/drug therapy/*mortality
MH  - Virginia/epidemiology
EDAT- 2003/10/29 05:00
MHDA- 2004/09/25 05:00
CRDT- 2003/10/29 05:00
PHST- 2003/10/29 05:00 [pubmed]
PHST- 2004/09/25 05:00 [medline]
PHST- 2003/10/29 05:00 [entrez]
AID - 10.1212/01.wnl.0000082653.40257.0b [doi]
PST - ppublish
SO  - Neurology. 2003 Oct 28;61(8):1066-73. doi: 10.1212/01.wnl.0000082653.40257.0b.