PMID- 14582140
OWN - NLM
STAT- MEDLINE
DCOM- 20040702
LR  - 20220409
IS  - 1552-4841 (Print)
IS  - 1552-4841 (Linking)
VI  - 123B
IP  - 1
DP  - 2003 Nov 15
TI  - Association study of a brain-derived neurotrophic-factor genetic polymorphism and 
      major depressive disorders, symptomatology, and antidepressant response.
PG  - 19-22
AB  - Preclinical studies have shown that brain-derived neurotrophic factor (BDNF) may 
      be involved in both antidepressant action and the pathophysiology of major 
      depressive disorder (MDD). The present study tested the hypothesis that the 
      BDNF-gene Val66Met polymorphism is associated with MDD, its clinical 
      manifestations, and antidepressant response. To elucidate a genetic 
      predisposition of MDD, we studied BDNF-gene Val66Met polymorphism in 152 MDD 
      patients in 255 normal controls. We also examined the association of this 
      polymorphism and fluoxetine therapeutic response in 110 MDD patients who received 
      a 4-week fluoxetine treatment. No significant differences were demonstrated for 
      the genotype or allele frequency of the BDNF polymorphism comparing the MDD and 
      control groups. Further, no significant differences were noted comparing the 
      three-genotype groups for depressive-cluster symptoms. However, a trend (P = 
      0.086) to improved 4-week-fluoxetine antidepressant response was demonstrated for 
      heterozygous patients in comparison to homozygous analogs. This finding suggests 
      the BDNF polymorphism investigated plays no major role in the pathogenesis of 
      MDD.
CI  - Copyright 2003 Wiley-Liss, Inc.
FAU - Tsai, Shih-Jen
AU  - Tsai SJ
AD  - Department of Psychiatry, Veterans General Hospital-Taipei, Taipei, Taiwan, ROC.
FAU - Cheng, Chih-Ya
AU  - Cheng CY
FAU - Yu, Younger W-Y
AU  - Yu YW
FAU - Chen, Tai-Jui
AU  - Chen TJ
FAU - Hong, Chen-Jee
AU  - Hong CJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Med Genet B Neuropsychiatr Genet
JT  - American journal of medical genetics. Part B, Neuropsychiatric genetics : the 
      official publication of the International Society of Psychiatric Genetics
JID - 101235742
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 01K63SUP8D (Fluoxetine)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Antidepressive Agents/*therapeutic use
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Chromosomes, Human, Pair 11/genetics
MH  - Depressive Disorder, Major/drug therapy/*genetics
MH  - Female
MH  - Fluoxetine/pharmacology/*therapeutic use
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Genetic/*genetics
EDAT- 2003/10/29 05:00
MHDA- 2004/07/03 05:00
CRDT- 2003/10/29 05:00
PHST- 2003/10/29 05:00 [pubmed]
PHST- 2004/07/03 05:00 [medline]
PHST- 2003/10/29 05:00 [entrez]
AID - 10.1002/ajmg.b.20026 [doi]
PST - ppublish
SO  - Am J Med Genet B Neuropsychiatr Genet. 2003 Nov 15;123B(1):19-22. doi: 
      10.1002/ajmg.b.20026.