PMID- 14583282
OWN - NLM
STAT- MEDLINE
DCOM- 20040823
LR  - 20190922
IS  - 1386-1425 (Print)
IS  - 1386-1425 (Linking)
VI  - 59
IP  - 13
DP  - 2003 Nov
TI  - Aluminum ions accelerated the oxidative stress of copper-mediated melanin 
      formation.
PG  - 3075-83
AB  - A comparison between the effects of aluminum and cupric ions on the dopachrome 
      (DC) conversion and the cooperation effect of the both ions in the DOPA oxidation 
      to melanin pathway has been studied by UV-Vis spectrophotometric method. Both 
      aluminum and cupric ions catalyze the DC conversion reaction, which is an 
      important step in the melanin synthesis pathway. However, cupric ions catalyze 
      the conversion of DC to yield 5,6-dihydroxyindole-2-carboxylic acid (DHICA) but 
      the product of DC conversion catalyzed by aluminum is 5,6-dihydroxyindole (DHI). 
      DOPA oxidation catalyzed by aluminum and cupric ions is studied in the presence 
      of hydrogen peroxide. The results from our experiments provide evidence that 
      aluminum can markedly increase the oxidative stress of copper-mediated the 
      melanin formation and influence the properties of the melanin by means of 
      changing the ratio of DHICA/DHI in the acidic environment (pH 5.5).
FAU - Di, Junwei
AU  - Di J
AD  - Department of Chemistry, The State Key Laboratory of Coordination Chemistry of 
      China, Nanjing University, 22 Hankou Road, Nanjing 210093, China.
FAU - Bi, Shuping
AU  - Bi S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Spectrochim Acta A Mol Biomol Spectrosc
JT  - Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
JID - 9602533
RN  - 0 (Cations)
RN  - 0 (Indolequinones)
RN  - 0 (Melanins)
RN  - 3571-34-4 (dopachrome)
RN  - 63-84-3 (Dihydroxyphenylalanine)
RN  - 789U1901C5 (Copper)
RN  - CPD4NFA903 (Aluminum)
SB  - IM
MH  - *Aluminum
MH  - Cations
MH  - Copper/*chemistry
MH  - Dihydroxyphenylalanine/*chemistry
MH  - Electrochemistry/methods
MH  - Indolequinones/*chemistry
MH  - Melanins/chemical synthesis/*chemistry
MH  - Oxidative Stress/*physiology
MH  - Spectrophotometry/methods
MH  - Spectrophotometry, Infrared
EDAT- 2003/10/30 05:00
MHDA- 2004/08/24 05:00
CRDT- 2003/10/30 05:00
PHST- 2003/10/30 05:00 [pubmed]
PHST- 2004/08/24 05:00 [medline]
PHST- 2003/10/30 05:00 [entrez]
AID - S1386142503001276 [pii]
AID - 10.1016/s1386-1425(03)00127-6 [doi]
PST - ppublish
SO  - Spectrochim Acta A Mol Biomol Spectrosc. 2003 Nov;59(13):3075-83. doi: 
      10.1016/s1386-1425(03)00127-6.