PMID- 14583308
OWN - NLM
STAT- MEDLINE
DCOM- 20040325
LR  - 20220409
IS  - 1010-7940 (Print)
IS  - 1010-7940 (Linking)
VI  - 24
IP  - 5
DP  - 2003 Nov
TI  - Changes in health-related quality of life and functional capacity following 
      coronary artery bypass graft surgery.
PG  - 750-6
AB  - OBJECTIVE: Improvement in survival and quality of life are the primary 
      indications for coronary artery bypass graft (CABG) operations. Among elderly 
      patients the main goal of surgery is not necessarily to prolong life, but to 
      improve the health-related quality of life. Factors associated with mortality and 
      morbidity following CABG surgery have been well defined, but the quality of life 
      and functional capacity in elderly patients undergoing CABG are poorly 
      documented. The aim here was to investigate changes in health-related quality of 
      life, overall performance status and symptomatic status during 1 year after CABG 
      surgery. METHODS: Comprehensive data on 508 CABG patients were prospectively 
      collected, including preoperative risk factors and postoperative morbidity in a 
      surgical center and in all eighteen secondary referral hospitals up to discharge. 
      The RAND-36 Health Survey (RAND-36) was used as indicator of quality of life. The 
      primary outcome was change in the physical component summary, mental component 
      summary and General Health summary scores from the RAND-36. Karnofsky dependency 
      category was used to assess overall performance status, and symptomatic status 
      was estimated according to New York Heart Association (NYHA) class. All 
      assessments were made preoperatively and repeated 12 months later. Analysis was 
      based on three age groups: 64 years or less (282 patients), 65-74 years (175 
      patients), and 75 or more years (51 patients). RESULTS: Thirty-day and 1-year 
      survival rates were 98.2 and 96.7%, respectively. A great majority (86.4%) of the 
      patients recovered without major complication. In all, the present data showed 
      significant improvement in all eight domains of QOL as well as in functional 
      capacity and NYHA class during the 1st year after CABG. However, the mean change 
      in RAND-36 Mental Component Summary scores among patients aged 75 years or more 
      did not reach a statistically significant level (P=0.097) and they had 
      significantly minor improvement as compared to younger patients (P<0.05). 
      Moreover, their General Health score improvement was poorer and statistically 
      insignificant (P=0.817). CONCLUSIONS: Elderly patients not only have higher 
      mortality and morbidity but also derive less benefit from CABG regarding certain 
      aspects of QOL.
FAU - Jarvinen, Otso
AU  - Jarvinen O
AD  - Department of Cardiothoracic Surgery, Tampere University Hospital, Tampere, 
      Finland. otsojarvinen@koti.sson.fi
FAU - Saarinen, Timo
AU  - Saarinen T
FAU - Julkunen, Juhani
AU  - Julkunen J
FAU - Huhtala, Heini
AU  - Huhtala H
FAU - Tarkka, Matti R
AU  - Tarkka MR
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Eur J Cardiothorac Surg
JT  - European journal of cardio-thoracic surgery : official journal of the European 
      Association for Cardio-thoracic Surgery
JID - 8804069
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Coronary Artery Bypass/*rehabilitation
MH  - Female
MH  - Follow-Up Studies
MH  - Health Status Indicators
MH  - Humans
MH  - Karnofsky Performance Status
MH  - Male
MH  - Middle Aged
MH  - Postoperative Period
MH  - Prospective Studies
MH  - *Quality of Life
MH  - Recovery of Function
MH  - Risk Factors
MH  - Treatment Outcome
MH  - Ventricular Function, Left
EDAT- 2003/10/30 05:00
MHDA- 2004/03/26 05:00
CRDT- 2003/10/30 05:00
PHST- 2003/10/30 05:00 [pubmed]
PHST- 2004/03/26 05:00 [medline]
PHST- 2003/10/30 05:00 [entrez]
AID - S1010794003004135 [pii]
AID - 10.1016/s1010-7940(03)00413-5 [doi]
PST - ppublish
SO  - Eur J Cardiothorac Surg. 2003 Nov;24(5):750-6. doi: 
      10.1016/s1010-7940(03)00413-5.