PMID- 14583394
OWN - NLM
STAT- MEDLINE
DCOM- 20040121
LR  - 20220310
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 351
IP  - 2
DP  - 2003 Nov 13
TI  - Serum brain-derived neurotrophic factor (BDNF) levels in schizophrenia are 
      indistinguishable from controls.
PG  - 111-4
AB  - Our previous study showed that serum brain-derived neurotrophic factor (BDNF) was 
      significantly decreased in the antidepressant-naive patients with major 
      depressive disorders. However, it was still unclear whether serum BDNF level was 
      altered in drug-naive patients with schizophrenia. Using ELISA, we measured serum 
      BDNF levels in antipsychotic-naive (n=15) and medicated (n=25) patients with 
      schizophrenia, and in age- and sex-matched normal controls (n=40). There were no 
      significant differences in serum BDNF levels among antipsychotic-naive (n=15) and 
      medicated (n=25) patients and normal controls (n=40). Possible factors such as 
      duration of illness, age of onset, Brief Psychiatric Rating Scale scores, and 
      chlorpromazine equivalent dosages of antipsychotics did not reveal any 
      significant correlations with BDNF levels. Our results do not support the view 
      that serum BDNF levels are associated with schizophrenia.
FAU - Shimizu, Eiji
AU  - Shimizu E
AD  - Department of Psychiatry, Graduate School of Medicine, Chiba University, 1-8-1 
      Inohana, Chuou-ku, Chiba 260-8670, Japan. eiji@faculty.chiba-u.jp
FAU - Hashimoto, Kenji
AU  - Hashimoto K
FAU - Watanabe, Hiroyuki
AU  - Watanabe H
FAU - Komatsu, Naoya
AU  - Komatsu N
FAU - Okamura, Naoe
AU  - Okamura N
FAU - Koike, Kaori
AU  - Koike K
FAU - Shinoda, Naoyuki
AU  - Shinoda N
FAU - Nakazato, Michiko
AU  - Nakazato M
FAU - Kumakiri, Chikara
AU  - Kumakiri C
FAU - Okada, Sin-ichi
AU  - Okada S
FAU - Iyo, Masaomi
AU  - Iyo M
LA  - eng
PT  - Journal Article
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Antipsychotic Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Adult
MH  - Age of Onset
MH  - Aged
MH  - Antipsychotic Agents/pharmacology
MH  - Brain/growth & development/*metabolism/*physiopathology
MH  - Brain-Derived Neurotrophic Factor/*blood/drug effects
MH  - Dopamine/metabolism
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neurons/metabolism
MH  - Schizophrenia/*blood/physiopathology
EDAT- 2003/10/30 05:00
MHDA- 2004/01/22 05:00
CRDT- 2003/10/30 05:00
PHST- 2003/10/30 05:00 [pubmed]
PHST- 2004/01/22 05:00 [medline]
PHST- 2003/10/30 05:00 [entrez]
AID - S0304394003009728 [pii]
AID - 10.1016/j.neulet.2003.08.004 [doi]
PST - ppublish
SO  - Neurosci Lett. 2003 Nov 13;351(2):111-4. doi: 10.1016/j.neulet.2003.08.004.