PMID- 14584384
OWN - NLM
STAT- MEDLINE
DCOM- 20040109
LR  - 20190513
IS  - 0035-9203 (Print)
IS  - 0035-9203 (Linking)
VI  - 97
IP  - 2
DP  - 2003 Mar-Apr
TI  - Involvement of interleukin-18 in severe Plasmodium falciparum malaria.
PG  - 236-41
AB  - Serum levels of interleukin-18 (IL-18), interferon-gamma (IFN-gamma), and 
      immunoglobulin E (IgE) were determined for 96 patients with Plasmodium falciparum 
      malaria admitted to hospital, Bangkok, Thailand in the period 1998-2000. The 
      patients were divided into 3 groups, i.e. uncomplicated, severe and cerebral 
      malaria according to WHO criteria (2000). Elevation of IL-18 levels was observed 
      in all 3 groups, with a tendency for higher levels in cases with severe malaria 
      throughout the course of the disease. Moreover, there was a significant 
      correlation between IL-18 levels and the extent of parasitaemia among patients 
      with severe malaria. However, IL-18 levels decreased more significantly in 
      patients with cerebral malaria compared with the other groups in the late stage 
      of the disease. Elevated levels of IFN-gamma were also observed in all groups of 
      patients, especially in those with severe or cerebral malaria, and the levels in 
      patients with cerebral malaria remained significantly higher than in those with 
      uncomplicated malaria during days 4-7 post-treatment, suggesting the involvement 
      of IFN-gamma in disease severity. Meanwhile, no significant difference was 
      observed in IgE levels between the severe and uncomplicated groups of patients 
      with helminth infection, although IgE levels were significantly higher in 
      helminth-infected patients than uninfected patients. These results suggest that 
      IL-18 plays a key role in inducing severe malaria through another pathway, such 
      as elevation of IFN-gamma, rather than its IgE inducing activity.
FAU - Nagamine, Yukiko
AU  - Nagamine Y
AD  - Department of Parasitology, Institute of Medical Science, University of Tokyo, 
      Tokyo, Japan.
FAU - Hayano, Masashi
AU  - Hayano M
FAU - Kashiwamura, Shin-ichiro
AU  - Kashiwamura S
FAU - Okamura, Haruki
AU  - Okamura H
FAU - Nakanishi, Kenji
AU  - Nakanishi K
FAU - Krudsod, Srivicha
AU  - Krudsod S
FAU - Wilairatana, Polrat
AU  - Wilairatana P
FAU - Looareesuwan, Sornchai
AU  - Looareesuwan S
FAU - Kojima, Somei
AU  - Kojima S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - England
TA  - Trans R Soc Trop Med Hyg
JT  - Transactions of the Royal Society of Tropical Medicine and Hygiene
JID - 7506129
RN  - 0 (Interleukin-18)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Interferon-gamma/blood
MH  - Interleukin-18/*blood
MH  - Malaria, Cerebral/blood
MH  - Malaria, Falciparum/*blood
MH  - Male
MH  - Middle Aged
EDAT- 2003/10/31 05:00
MHDA- 2004/01/10 05:00
CRDT- 2003/10/31 05:00
PHST- 2003/10/31 05:00 [pubmed]
PHST- 2004/01/10 05:00 [medline]
PHST- 2003/10/31 05:00 [entrez]
AID - 10.1016/s0035-9203(03)90130-1 [doi]
PST - ppublish
SO  - Trans R Soc Trop Med Hyg. 2003 Mar-Apr;97(2):236-41. doi: 
      10.1016/s0035-9203(03)90130-1.