PMID- 14586106
OWN - NLM
STAT- MEDLINE
DCOM- 20040726
LR  - 20131121
IS  - 0916-8451 (Print)
IS  - 0916-8451 (Linking)
VI  - 67
IP  - 10
DP  - 2003 Oct
TI  - Inhibition of immunoglobulin E production in allergic model mice by 
      supplementation with vitamin E and beta-carotene.
PG  - 2176-82
AB  - A diet containing different amounts of vitamin E (alpha-tocopherol; 0.5 mg, 5 mg, 
      10 mg or 50 mg per 100 g diet) was supplemented to BALB/c mice for 6 weeks. These 
      mice were subcutaneously immunized twice with ovalbumin (OVA). A passive 
      cutaneous anaphylaxis (PCA) analysis demonstrated that the mice fed on the diet 
      containing 5 mg of vitamin E produced the highest level of the OVA-specific 
      immunoglobulin E (IgE) antibody. A lower level of serum IgE was found in the mice 
      supplemented with 0.5 mg, 10 mg and 50 mg of vitamin E. A sandwich ELISA analysis 
      showed that the pattern of the total IgE antibody level among these four groups 
      was the same as that of the allergen-specific IgE. In a separate experiment, 5 mg 
      of vitamin E and/or 50 mg of beta-carotene was supplemented to the basal diet 
      containing vitamin E as alpha-tocopherol acetate (5 mg) in order to evaluate the 
      effect of their combination on OVA-specific and total IgE production in the mice. 
      The supplementation with beta-carotene alone had no effect on OVA-specific or 
      total IgE production. In contrast, supplementation with vitamin E plus 
      beta-carotene effectively suppressed both the antigen-specific and total IgE 
      antibodies. The serum vitamin E and beta-carotene levels were increased by 
      supplementation with the respective compounds. These results strongly suggest 
      that the combination of dietary vitamin E and beta-carotene suppressed IgE 
      production and would therefore help to prevent the type-I allergic reaction.
FAU - Bando, Noriko
AU  - Bando N
AD  - Department of Nutrition, School of Medicine, The University of Tokushima, 
      Tokushima, Japan.
FAU - Yamanishi, Rintaro
AU  - Yamanishi R
FAU - Terao, Junji
AU  - Terao J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Biosci Biotechnol Biochem
JT  - Bioscience, biotechnology, and biochemistry
JID - 9205717
RN  - 0 (Antibodies)
RN  - 01YAE03M7J (beta Carotene)
RN  - 1406-18-4 (Vitamin E)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 9006-59-1 (Ovalbumin)
SB  - IM
MH  - Animals
MH  - Antibodies/blood
MH  - Antibody Formation/*drug effects
MH  - Dietary Supplements
MH  - Drug Therapy, Combination
MH  - Female
MH  - Hypersensitivity/drug therapy/*prevention & control
MH  - Immunization
MH  - Immunoglobulin E/*biosynthesis/blood/drug effects
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Ovalbumin/administration & dosage/immunology
MH  - Rats
MH  - Rats, Wistar
MH  - Vitamin E/*administration & dosage/blood/pharmacology
MH  - beta Carotene/*administration & dosage/blood/pharmacology
EDAT- 2003/10/31 05:00
MHDA- 2004/07/28 05:00
CRDT- 2003/10/31 05:00
PHST- 2003/10/31 05:00 [pubmed]
PHST- 2004/07/28 05:00 [medline]
PHST- 2003/10/31 05:00 [entrez]
AID - 10.1271/bbb.67.2176 [doi]
PST - ppublish
SO  - Biosci Biotechnol Biochem. 2003 Oct;67(10):2176-82. doi: 10.1271/bbb.67.2176.