PMID- 14586160
OWN - NLM
STAT- MEDLINE
DCOM- 20040130
LR  - 20220410
IS  - 0302-282X (Print)
IS  - 0302-282X (Linking)
VI  - 48
IP  - 3
DP  - 2003
TI  - Chronic, but not acute, clomipramine or fluoxetine treatment reduces the 
      spontaneous firing rate in the mesoaccumbens neurons of the rat.
PG  - 116-23
AB  - In the present study, single-unit extracellular recording was used in male Wistar 
      rats to compare the effects of a single dose (acute treatment) and a 21-day 
      regimen (long-term treatment) with clomipramine (2.5 mg/kg) and fluoxetine (1.0 
      mg/kg) on the spontaneous firing rate of nucleus accumbens (NAcc) neurons 
      connected with the ventral tegmental area (VTA). A single injection of 
      clomipramine or fluoxetine did not modify the firing rate of NAcc neurons as 
      compared with the control group, whereas a 21-day regimen reduced the firing rate 
      in comparison with a 21-day saline-treated group, specifically for NAcc neurons 
      that were inhibited by VTA electrical stimulation. These results demonstrate that 
      chronic, but not acute, clomipramine or fluoxetine treatment reduces the firing 
      rate of mesoaccumbens neurons, probably by dopaminergic activation, supporting 
      the hypothesis that the NAcc is involved in the actions of at least these 
      antidepressants. However, additional experiments need to be performed in order to 
      delineate the mechanisms by which chronic clomipramine and fluoxetine treatment 
      reduces the firing rate of NAcc neurons in the rat.
CI  - Copyright 2003 S. Karger AG, Basel
FAU - Rodriguez-Landa, Juan Francisco
AU  - Rodriguez-Landa JF
AD  - Laboratorio de Neurofarmacologia, Instituto de Neuroetologia, Universidad 
      Veracruzana, y Instituto de Investigaciones Biomedicas, Universidad Nacional 
      Autonoma de Mexico, Xalapa, Veracruz, Mexico.
FAU - Contreras, Carlos M
AU  - Contreras CM
FAU - Gutierrez-Garcia, Ana G
AU  - Gutierrez-Garcia AG
FAU - Bernal-Morales, Blandina
AU  - Bernal-Morales B
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Neuropsychobiology
JT  - Neuropsychobiology
JID - 7512895
RN  - 0 (Antidepressive Agents)
RN  - 01K63SUP8D (Fluoxetine)
RN  - NUV44L116D (Clomipramine)
SB  - IM
MH  - Action Potentials
MH  - Animals
MH  - Antidepressive Agents/*administration & dosage/pharmacology
MH  - Clomipramine/*administration & dosage/pharmacology
MH  - Drug Administration Schedule
MH  - Fluoxetine/*administration & dosage/pharmacology
MH  - Male
MH  - Neurons/*drug effects/physiology
MH  - Nucleus Accumbens/*drug effects/physiology
MH  - Rats
MH  - Rats, Wistar
MH  - Time Factors
EDAT- 2003/10/31 05:00
MHDA- 2004/01/31 05:00
CRDT- 2003/10/31 05:00
PHST- 2003/10/31 05:00 [pubmed]
PHST- 2004/01/31 05:00 [medline]
PHST- 2003/10/31 05:00 [entrez]
AID - 73627 [pii]
AID - 10.1159/000073627 [doi]
PST - ppublish
SO  - Neuropsychobiology. 2003;48(3):116-23. doi: 10.1159/000073627.