PMID- 1458696
OWN - NLM
STAT- MEDLINE
DCOM- 19930113
LR  - 20170112
IS  - 0392-856X (Print)
IS  - 0392-856X (Linking)
VI  - 10
IP  - 5
DP  - 1992 Sep-Oct
TI  - Systemic lupus erythematosus and pregnancy: a prospective study.
PG  - 439-46
AB  - We have prospectively followed 25 pregnancies in 21 patients: 20 were affected by 
      systemic lupus erythematosus (SLE) and 1 by subacute cutaneous lupus 
      erythematosus (SCLE). A flexible treatment schedule was applied to the follow-up 
      of all the pregnancies, and included low dose aspirin, steroids at medium-low 
      dosage and, if needed, azathioprine (AZA) after 20 weeks of gestation. There were 
      4 spontaneous first trimester abortions and 21 live-born neonates without major 
      problems related to the treatment or to the maternal disease. The relapse rate of 
      the disease recorded during the observation period was 0.07 patient/month, not 
      different from that already reported in SLE patients (pregnant or nonpregnant). 
      Obstetrical complications were relatively frequent, but careful monitoring 
      allowed us to avoid late fetal wastage. We conclude that in SLE patients a 
      successful pregnancy outcome, without worsening of the disease, can be obtained 
      with a careful multidisciplinary follow-up.
FAU - Tincani, A
AU  - Tincani A
AD  - Clinical Immunology Unit, Brescia General Hospital, Italy.
FAU - Faden, D
AU  - Faden D
FAU - Tarantini, M
AU  - Tarantini M
FAU - Lojacono, A
AU  - Lojacono A
FAU - Tanzi, P
AU  - Tanzi P
FAU - Gastaldi, A
AU  - Gastaldi A
FAU - Di Mario, C
AU  - Di Mario C
FAU - Spatola, L
AU  - Spatola L
FAU - Cattaneo, R
AU  - Cattaneo R
FAU - Balestrieri, G
AU  - Balestrieri G
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - Clin Exp Rheumatol
JT  - Clinical and experimental rheumatology
JID - 8308521
RN  - 0 (Steroids)
RN  - MRK240IY2L (Azathioprine)
RN  - R16CO5Y76E (Aspirin)
SB  - IM
CIN - Clin Exp Rheumatol. 1992 Sep-Oct;10(5):429-31. PMID: 1458694
MH  - Adult
MH  - Aspirin/therapeutic use
MH  - Azathioprine/therapeutic use
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Lupus Erythematosus, Systemic/*complications/drug therapy/*epidemiology
MH  - Pregnancy
MH  - Pregnancy Complications/drug therapy/*epidemiology
MH  - Pregnancy Outcome
MH  - Prospective Studies
MH  - Steroids/therapeutic use
EDAT- 1992/09/01 00:00
MHDA- 1992/09/01 00:01
CRDT- 1992/09/01 00:00
PHST- 1992/09/01 00:00 [pubmed]
PHST- 1992/09/01 00:01 [medline]
PHST- 1992/09/01 00:00 [entrez]
PST - ppublish
SO  - Clin Exp Rheumatol. 1992 Sep-Oct;10(5):439-46.