PMID- 14587046
OWN - NLM
STAT- MEDLINE
DCOM- 20031212
LR  - 20041117
IS  - 0361-8609 (Print)
IS  - 0361-8609 (Linking)
VI  - 74
IP  - 3
DP  - 2003 Nov
TI  - Rhinolalia as a presenting sign of pneumomediastinum complicating post peripheral 
      blood stem cell transplantation bronchiolitis obliterans.
PG  - 182-6
AB  - A 26-year-old male with graft vs. host disease (GVHD) presented with rhinolalia 
      (a squeaky voice of nasal quality) as a presenting sign for pneumonasopharynx and 
      pneumomediastinum secondary to bronchiolitis obliterans. The patient underwent 
      HLA-identical related peripheral blood stem cells transplantation 8 months before 
      the diagnosis. Three weeks after transplantation he began to suffer from GVHD 
      Grade III that involved the gut, liver, and skin and later on the lungs. Due to 
      severe obstructive bronchiolitis obliterans the patient developed intensive cough 
      evolving into pneumomediastinum and pneumonasopharynx with rhinolalia. The 
      patient was treated conservatively with complete resolution. Although rare, 
      pneumomediastinum and pneumonasopharynx can be a life-threatening event, and one 
      should be aware of the signs and symptoms on physical examination, which may be 
      as subtle as rhinolalia alone.
CI  - Copyright 2003 Wiley-Liss, Inc.
FAU - Bitan, M
AU  - Bitan M
AD  - Department of Bone Marrow Transplantation & Cancer Immunotherapy, Hadassah 
      University Hospital, Jerusalem, Israel. mbitan@hadassah.org.il
FAU - Resnick, I B
AU  - Resnick IB
FAU - Or, R
AU  - Or R
FAU - Rokach, A
AU  - Rokach A
FAU - Laxer, U
AU  - Laxer U
FAU - Ackerstein, A
AU  - Ackerstein A
FAU - Elad, S
AU  - Elad S
FAU - Slavin, S
AU  - Slavin S
FAU - Shapira, M Y
AU  - Shapira MY
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Am J Hematol
JT  - American journal of hematology
JID - 7610369
SB  - IM
MH  - Adult
MH  - Bronchiolitis Obliterans/*complications/diagnosis/etiology
MH  - Graft vs Host Disease/pathology
MH  - Humans
MH  - Male
MH  - Mediastinal Emphysema/complications/*diagnosis/etiology
MH  - Nasopharynx/pathology
MH  - Peripheral Blood Stem Cell Transplantation/*adverse effects
MH  - Speech Disorders/*etiology
MH  - Tomography, X-Ray Computed
MH  - Transplantation, Homologous
EDAT- 2003/10/31 05:00
MHDA- 2003/12/13 05:00
CRDT- 2003/10/31 05:00
PHST- 2003/10/31 05:00 [pubmed]
PHST- 2003/12/13 05:00 [medline]
PHST- 2003/10/31 05:00 [entrez]
AID - 10.1002/ajh.10419 [doi]
PST - ppublish
SO  - Am J Hematol. 2003 Nov;74(3):182-6. doi: 10.1002/ajh.10419.