PMID- 14587217 OWN - NLM STAT- MEDLINE DCOM- 20031212 LR - 20061115 IS - 0021-2571 (Print) IS - 0021-2571 (Linking) VI - 39 IP - 2 DP - 2003 TI - [Nerve growth factor and brain-derived neurotrophic factor: a possible etiopathogenic role in sensorineural hearing loss. Preliminary data]. PG - 189-94 AB - Nerve growth factor (NGF) and brain derived neurotrophic factor (BDNF) are members of a family of structurally related secreted proteins, termed neurotrophins, which promote and regulate the survival of many kinds of neurons in the peripheral nervous system. Aim of the study is to dose the serum level of NGF and BDNF in 8 patients affected by sensorineural hearing loss (SNHL). The results show that in these patients the amount of circulating NGF, but not of BDNF, is significantly lower in comparison to that found in age-matched controls. The preliminary data of the present study suggest that NGF might have a crucial role in the auditory pathway, promoting the survival and preventing the degeneration of sensorineural cells. FAU - Salvinelli, Fabrizio AU - Salvinelli F AD - Area di Otorinolaringoiatria, Universita Campus Bio-Medico, Via Longoni 83, 00155 Roma. f.salvinelli@unicampus.it FAU - Antonelli, Alessia AU - Antonelli A FAU - Stampachiacchiere, Barbara AU - Stampachiacchiere B FAU - Bianchi di Castelbianco, Federico AU - Bianchi di Castelbianco F FAU - Casale, Manuele AU - Casale M FAU - D'Ascanio, Luca AU - D'Ascanio L FAU - Greco, Fabio AU - Greco F FAU - Aloe, Luigi AU - Aloe L LA - ita PT - English Abstract PT - Journal Article PT - Research Support, Non-U.S. Gov't TT - Nerve growth factor e brain derived neurotrophic factor: un possibile ruolo eziopatogenico nell'ipoacusia neurosensoriale. Dati preliminari. PL - Italy TA - Ann Ist Super Sanita JT - Annali dell'Istituto superiore di sanita JID - 7502520 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 9061-61-4 (Nerve Growth Factor) SB - IM MH - Adolescent MH - Adult MH - Brain-Derived Neurotrophic Factor/*blood MH - Case-Control Studies MH - Child MH - Female MH - Hearing Loss, Sensorineural/*blood/etiology MH - Humans MH - Male MH - Middle Aged MH - Nerve Growth Factor/blood/deficiency/*physiology EDAT- 2003/11/01 05:00 MHDA- 2003/12/13 05:00 CRDT- 2003/11/01 05:00 PHST- 2003/11/01 05:00 [pubmed] PHST- 2003/12/13 05:00 [medline] PHST- 2003/11/01 05:00 [entrez] PST - ppublish SO - Ann Ist Super Sanita. 2003;39(2):189-94.