PMID- 14587253
OWN - NLM
STAT- MEDLINE
DCOM- 20031125
LR  - 20190922
IS  - 0025-8105 (Print)
IS  - 0025-8105 (Linking)
VI  - 56
IP  - 7-8
DP  - 2003 Jul-Aug
TI  - [Effect of proteinuria on tubulointerstitial damage].
PG  - 351-4
AB  - INTRODUCTION: Glomerular basal membrane represents a mechanical and electric 
      barrier for plasma proteins. In physiological conditions only plasma proteins of 
      low molecular weight are completely filtered through basal membrane. Due to 
      damages of glomerular basal membrane there is an increase in filtration of plasma 
      proteins of moderate and high molecular weight. PROTEINURIA: In regard to its 
      etiology proteinuria can be prerenal, renal and postrenal. By analyzing albumin, 
      1-microglobulin, immunoglobulin G and 2-macroglobulin, together with total 
      protein in urine, it is possible to detect and differentiate causes of prerenal, 
      glomerular, tubular and postrenal proteinuria. Abnormal glomerular permeability 
      to macromolecules results in excessive protein delivery and reabsorption in 
      proximal tubules. Excessive reabsorption in turn may cause congetion of 
      intracellular endocytic and biosynthetic compartments leading to NFkB-dependent 
      and -independent gene upregulation. Among those genes, monocyte chemoattractant 
      protein-1 (MCP-1), cytokines, osteopontin and endothelin stimulate processes of 
      interstitial inflammation and fibroblast proliferation and are ultimately 
      responsible for enhanced extracellular matrix deposition and renal scarring. 
      Human tubular cells exposed to albumin and HDL increase production of 
      endothelin-1. Endothelin-1 affects microcirculation and fibroblasts and is a 
      monocyte chemoattractant. Specific proteins that are cytotoxic are 
      transferrin/iron, low-density lipoprotein, and complement components, all of 
      which appear in urine in proteinuric states. Adequate and early diagnosis and 
      differentiation of proteinuria are of immense therapeutic importance.
FAU - Stojimirovic, Biljana
AU  - Stojimirovic B
AD  - Klinika za nefrologiju, Institut za urologiju i nefrologiju, Klinicki centar 
      Srbije, Beograd. bistoj@ptt.yu
FAU - Petrovic, Dejan
AU  - Petrovic D
LA  - hrv
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Uticaj proteinurije na ostecenje tubulointersticijuma.
PL  - Serbia
TA  - Med Pregl
JT  - Medicinski pregled
JID - 2985249R
SB  - IM
MH  - Humans
MH  - Kidney Diseases/*physiopathology/urine
MH  - Kidney Tubules/*physiopathology
MH  - Nephritis, Interstitial/physiopathology/urine
MH  - Proteinuria/*physiopathology
RF  - 24
EDAT- 2003/11/01 05:00
MHDA- 2003/12/03 05:00
CRDT- 2003/11/01 05:00
PHST- 2003/11/01 05:00 [pubmed]
PHST- 2003/12/03 05:00 [medline]
PHST- 2003/11/01 05:00 [entrez]
AID - 10.2298/mpns0308351s [doi]
PST - ppublish
SO  - Med Pregl. 2003 Jul-Aug;56(7-8):351-4. doi: 10.2298/mpns0308351s.