PMID- 14588097
OWN - NLM
STAT- MEDLINE
DCOM- 20040603
LR  - 20061115
IS  - 1050-7256 (Print)
IS  - 1050-7256 (Linking)
VI  - 13
IP  - 9
DP  - 2003 Sep
TI  - Polymorphism in the transmembrane region of the major histocompatibility complex 
      class I chain-related gene A: association of five GCT repetitions with Graves' 
      disease in children.
PG  - 839-43
AB  - Graves' disease is an autoimmune disease involving a complex interplay of 
      multiple genetic and environmental influences. An association between the 
      disorder and the major histocompatibility complex (MHC; human leukocyte antigen 
      [HLA]) region has long been reported. The major histocompatibility complex class 
      I chain-related gene A (MICA) has a triplet repeat polymorphism in the 
      transmembrane region consisting of six alleles. For this study, the polymorphism 
      in question was analyzed for 129 unrelated children with Graves' disease (97 
      girls and 32 boys, 10.0 +/- 3.0 years of age) and 396 randomly selected, 
      unrelated subjects (205 females, 191 males, 8.4 +/- 13.5 years of age). The 
      frequencies of genotype A5/A5 and A5/A5.1 were significantly higher in patients 
      than in controls (relative risk [RR] = 2.49, 95% confidence interval [CI] 
      1.52-4.10, p = 0.00024, pc = 0.0035 and RR = 2.13, 95% CI 1.31-3.47, p = 0.0020, 
      pc = 0.030; respectively). The frequency of genotype A5.1/A5.1 was significantly 
      lower in patients than in controls (RR = 0.09, 95% CI 0.01-0.66, p = 0.0030, pc = 
      0.044). Allele frequency for allele A5 was significantly higher for children with 
      Graves' disease compared to controls (RR = 2.12; 95% CI = 1.59-2.82; p = 1.9 x 
      10(-7); pc = 9.5 x 10(-7)). This study demonstrates that MICA allele A5 confers 
      the risk for Graves' disease.
FAU - Lo, Fu-Sung
AU  - Lo FS
AD  - Department of Pediatrics, Chang Gung Children's Hospital, Tao-Yuang, Taiwan.
FAU - Lee, Yann-Jinn
AU  - Lee YJ
FAU - Huang, Chi-Yu
AU  - Huang CY
FAU - Lin, Chao-Hsu
AU  - Lin CH
FAU - Chang, Shih-Chuan
AU  - Chang SC
FAU - Dang, Ching-Wen
AU  - Dang CW
FAU - Liu, Hsin-Fu
AU  - Liu HF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Thyroid
JT  - Thyroid : official journal of the American Thyroid Association
JID - 9104317
RN  - 0 (Membrane Proteins)
SB  - IM
MH  - Adolescent
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Gene Frequency
MH  - Genes, MHC Class I/*genetics
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Graves Disease/*genetics/immunology
MH  - Humans
MH  - Male
MH  - Membrane Proteins/*genetics
MH  - Polymorphism, Genetic/genetics
MH  - Trinucleotide Repeats/*genetics
EDAT- 2003/11/01 05:00
MHDA- 2004/06/04 05:00
CRDT- 2003/11/01 05:00
PHST- 2003/11/01 05:00 [pubmed]
PHST- 2004/06/04 05:00 [medline]
PHST- 2003/11/01 05:00 [entrez]
AID - 10.1089/105072503322401023 [doi]
PST - ppublish
SO  - Thyroid. 2003 Sep;13(9):839-43. doi: 10.1089/105072503322401023.