PMID- 14597108
OWN - NLM
STAT- MEDLINE
DCOM- 20040302
LR  - 20190827
IS  - 0165-5728 (Print)
IS  - 0165-5728 (Linking)
VI  - 144
IP  - 1-2
DP  - 2003 Nov
TI  - Intrathecal synthesis of monocyte chemoattractant protein-1 (MCP-1) in 
      amyotrophic lateral sclerosis: further evidence for microglial activation in 
      neurodegeneration.
PG  - 139-42
AB  - Autopsy studies and animal experiments suggest that microglial inflammation 
      contributes to the pathogenesis of amyotrophic lateral sclerosis (ALS). 
      Monocyte-chemoattractant protein (MCP-1) might play an important role in 
      microglial recruitment. We studied MCP-1 levels in sera and cerebrospinal fluid 
      of 29 ALS patients and compared the results with 11 control patients with tension 
      headache. The MCP-1 level was determined using enzyme-linked immunosorbent assays 
      (ELISA). A significant increase in cerebrospinal fluid MCP-1 level but not serum 
      level was seen in the patients with ALS compared to the control subjects. These 
      results suggest that cerebrospinal fluid MCP-1 activity may be a sensitive marker 
      for neuroinflammation in ALS useful for monitoring treatment trials in ALS.
FAU - Wilms, H
AU  - Wilms H
AD  - Klinik fur Neurologie, Christian-Albrechts-Universitat Kiel, Niemannsweg 147, 
      24105 Kiel, Germany. h.wilms@neurologie.uni-kiel.de
FAU - Sievers, J
AU  - Sievers J
FAU - Dengler, R
AU  - Dengler R
FAU - Bufler, J
AU  - Bufler J
FAU - Deuschl, G
AU  - Deuschl G
FAU - Lucius, R
AU  - Lucius R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
RN  - 0 (Cerebrospinal Fluid Proteins)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Age of Onset
MH  - Aged
MH  - Amyotrophic Lateral Sclerosis/*cerebrospinal fluid/immunology/*pathology
MH  - Analysis of Variance
MH  - Cell Movement/immunology
MH  - Cerebrospinal Fluid Proteins/*biosynthesis/blood/cerebrospinal fluid
MH  - Chemokine CCL2/*biosynthesis/blood/*cerebrospinal fluid
MH  - Humans
MH  - Microglia/immunology/*metabolism/*pathology
MH  - Middle Aged
MH  - Regression Analysis
MH  - Statistics, Nonparametric
MH  - Up-Regulation/immunology
EDAT- 2003/11/05 05:00
MHDA- 2004/03/03 05:00
CRDT- 2003/11/05 05:00
PHST- 2003/11/05 05:00 [pubmed]
PHST- 2004/03/03 05:00 [medline]
PHST- 2003/11/05 05:00 [entrez]
AID - S0165572803003576 [pii]
AID - 10.1016/j.jneuroim.2003.08.042 [doi]
PST - ppublish
SO  - J Neuroimmunol. 2003 Nov;144(1-2):139-42. doi: 10.1016/j.jneuroim.2003.08.042.