PMID- 14598048
OWN - NLM
STAT- MEDLINE
DCOM- 20031210
LR  - 20071115
IS  - 1590-1874 (Print)
IS  - 1590-1874 (Linking)
VI  - 24 Suppl 4
DP  - 2003 Oct
TI  - Treatment of multiple sclerosis with intravenous immunoglobulin: review of 
      clinical trials.
PG  - S227-30
AB  - Intravenous immunoglobulin (IVIG) is an established therapy for a number of 
      neuroimmune disorders, including Guillain-Barre syndrome and chronic inflammatory 
      demyelinating polyneuropathy. IVIG exerts a number of effects that may be 
      beneficial in multiple sclerosis (MS): reduction of inflammation, inhibition of 
      macrophages, and promotion of remyelination. Four double-blind trials have been 
      performed of IVIG in relapsing-remitting MS. A meta-analysis of the four trials 
      has shown that IVIG reduces the relapse rate, new MRI lesions, and disease 
      progression. IVIG does not seem to be of any benefit in chronic visual or motor 
      symptoms in MS. In secondary progressive MS, IVIG has not shown effect on disease 
      progression, relapses or new MRI lesions. In conclusion, IVIG is an alternative 
      second-line treatment to approved therapies in relapsing-remitting MS, but the 
      ideal dosage of IVIG still needs to be determined.
FAU - Sorensen, P S
AU  - Sorensen PS
AD  - MS Research Unit, Department of Neurology, Copenhagen University Hospital 
      Rigshospitalet, Copenhagen, Denmark.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Italy
TA  - Neurol Sci
JT  - Neurological sciences : official journal of the Italian Neurological Society and 
      of the Italian Society of Clinical Neurophysiology
JID - 100959175
RN  - 0 (Immunoglobulins, Intravenous)
SB  - IM
MH  - Clinical Trials as Topic
MH  - Humans
MH  - Immunoglobulins, Intravenous/*therapeutic use
MH  - Multiple Sclerosis/*drug therapy/physiopathology
MH  - Multiple Sclerosis, Relapsing-Remitting/drug therapy
RF  - 20
EDAT- 2003/11/05 05:00
MHDA- 2003/12/12 05:00
CRDT- 2003/11/05 05:00
PHST- 2003/11/05 05:00 [pubmed]
PHST- 2003/12/12 05:00 [medline]
PHST- 2003/11/05 05:00 [entrez]
AID - 10.1007/s10072-003-0083-5 [doi]
PST - ppublish
SO  - Neurol Sci. 2003 Oct;24 Suppl 4:S227-30. doi: 10.1007/s10072-003-0083-5.