PMID- 14598155 OWN - NLM STAT- MEDLINE DCOM- 20040312 LR - 20041117 IS - 0944-1166 (Print) IS - 0944-1166 (Linking) VI - 10 IP - 4 DP - 2003 TI - Surgical approach to tumor recurrence and metastatic lesions of the liver in a patient with malignant endocrine tumors of the pancreas: case report. PG - 325-8 AB - We describe herein a 72-year-old woman with tumor recurrence in the residual pancreas and metastasis to the liver following a pylorus-preserving pancreatoduodenectomy for multiple endocrine tumors in the head of the pancreas. Abdominal ultrasonography performed 7 years after the initial surgery detected new lesions in the residual pancreas and liver. After recurrence of endocrine tumors of the pancreas and metastasis to the liver were diagnosed, the lesions were successfully resected by total pancreatectomy with distal gastrectomy and both lateral segmentectomy and partial resection of segment 8. Genetic analysis using a blood specimen showed that this patient carried the multiple endocrine neoplasia type 1 (MEN1) gene mutation. One year after the second resection, the patient remains in good health using insulin and has not shown any sign of recurrence. This case report describes successful surgical resection for recurrence and metastasis of malignant endocrine tumors in a patient with the MEN1 gene mutation. FAU - Inagaki, Mitsuhiro AU - Inagaki M AD - Department of Surgery, JA Hokkaido Kouseiren Asahikawa Kousei Hospital, 1-24, Asahikawa 078-8211, Japan. FAU - Aoyagi, Takeshi AU - Aoyagi T FAU - Nomura, Atsushi AU - Nomura A FAU - Yokoo, Hideki AU - Yokoo H FAU - Akabane, Mitsuhiro AU - Akabane M FAU - Kawata, Akira AU - Kawata A FAU - Nakano, Shirou AU - Nakano S FAU - Chiba, Atsushi AU - Chiba A FAU - Fujii, Tsuneshi AU - Fujii T FAU - Sakurai, Hiroharu AU - Sakurai H FAU - Tsukada, Toshihiko AU - Tsukada T FAU - Takahashi, Masahiro AU - Takahashi M LA - eng PT - Case Reports PT - Journal Article PL - Japan TA - J Hepatobiliary Pancreat Surg JT - Journal of hepato-biliary-pancreatic surgery JID - 9431940 SB - IM MH - Aged MH - Digestive System Surgical Procedures/*methods MH - Female MH - Humans MH - Liver Neoplasms/genetics/physiopathology/secondary/*surgery MH - Multiple Endocrine Neoplasia Type 1/*genetics/physiopathology MH - Neoplasm Recurrence, Local/diagnosis/*surgery MH - Pancreatic Neoplasms/genetics/pathology/physiopathology/*surgery MH - Pancreaticoduodenectomy EDAT- 2003/11/05 05:00 MHDA- 2004/03/16 05:00 CRDT- 2003/11/05 05:00 PHST- 2002/07/01 00:00 [received] PHST- 2002/12/10 00:00 [accepted] PHST- 2003/11/05 05:00 [pubmed] PHST- 2004/03/16 05:00 [medline] PHST- 2003/11/05 05:00 [entrez] AID - 10.1007/s00534-002-0861-0 [doi] PST - ppublish SO - J Hepatobiliary Pancreat Surg. 2003;10(4):325-8. doi: 10.1007/s00534-002-0861-0.