PMID- 14598594 OWN - NLM STAT- MEDLINE DCOM- 20040402 LR - 20181130 IS - 0023-2149 (Print) IS - 0023-2149 (Linking) VI - 81 IP - 9 DP - 2003 TI - [Use of proton pump inhibitors in the treatment of gastroesophageal reflux disease]. PG - 54-9 AB - Gastroesophageal reflux disease (GERD) is a wide spread disease characterized by distinct clinical polymorphism manifesting with various symptoms and/or inflammatory changes of a distal portion of the esophagus. Current first-line therapy in GERD consists in administration of proton pump inhibitors (PPI) which promote faster relief of the symptoms and healing of erosive-ulcerous lesions of esophageal mucosa in GERD patients. Clinical efficacy of standard and novel PPI is compared. Wide use of PPI and their long-term courses require further study of PPI side effects which now lack attention from the clinical researchers. FAU - Maev, I V AU - Maev IV FAU - Balashova, N N AU - Balashova NN FAU - Busarova, G A AU - Busarova GA LA - rus PT - Journal Article PT - Review TT - Ispol'zovanie ingibitorov protonnoi pompy v lechenii gastroezofageal'noi refliuksnoi bolezni. PL - Russia (Federation) TA - Klin Med (Mosk) JT - Klinicheskaia meditsina JID - 2985204R RN - 0 (2-Pyridinylmethylsulfinylbenzimidazoles) RN - 0 (Benzimidazoles) RN - 0 (Enzyme Inhibitors) RN - 0 (Proton Pump Inhibitors) RN - 0 (Sulfoxides) RN - 0K5C5T2QPG (Lansoprazole) RN - 32828355LL (Rabeprazole) RN - D8TST4O562 (Pantoprazole) RN - KG60484QX9 (Omeprazole) SB - IM MH - 2-Pyridinylmethylsulfinylbenzimidazoles MH - Benzimidazoles/therapeutic use MH - Enzyme Inhibitors/therapeutic use MH - Gastroesophageal Reflux/*drug therapy MH - Humans MH - Lansoprazole MH - Omeprazole/*analogs & derivatives/therapeutic use MH - Pantoprazole MH - *Proton Pump Inhibitors MH - Rabeprazole MH - Sulfoxides/therapeutic use MH - Treatment Outcome RF - 51 EDAT- 2003/11/06 05:00 MHDA- 2004/04/03 05:00 CRDT- 2003/11/06 05:00 PHST- 2003/11/06 05:00 [pubmed] PHST- 2004/04/03 05:00 [medline] PHST- 2003/11/06 05:00 [entrez] PST - ppublish SO - Klin Med (Mosk). 2003;81(9):54-9.