PMID- 14600003
OWN - NLM
STAT- MEDLINE
DCOM- 20040421
LR  - 20190513
IS  - 0002-0729 (Print)
IS  - 0002-0729 (Linking)
VI  - 32
IP  - 6
DP  - 2003 Nov
TI  - The predictive validity for mortality of the index of mobility-related 
      limitation--results from the EPESE study.
PG  - 619-25
AB  - BACKGROUND: self-reported disability reflects physical, environmental and 
      attitudinal factors. We have previously reported the empirical identification of 
      three simple tests to provide an index of (ambulatory) mobility-related 
      physiological limitations (MOBLI). Evidence of the MOBLI 's responsiveness over 
      time has been presented. Evidence of the predictive validity of the index is 
      needed. OBJECTIVE: we aimed to measure the predictive validity for future 
      mortality of the MOBLI and of self-reported mobility disability in a longitudinal 
      cohort study. METHODS: data are from the sixth annual interview for two sites in 
      the Established Populations for Epidemiologic Studies of the Elderly study. 
      Included were 3,040 people, with information about self-reported walking 
      difficulties, walking speed, time to complete five chair stands and peak 
      expiratory flow. Age- and sex-adjusted death rates over a 4-year follow-up were 
      computed, and proportional hazards regression models were used in the analysis. 
      RESULTS: the MOBLI score is associated with subsequent mortality over 4 years, 
      with evidence of a 'dose-response' relationship. The predictive value for 
      mortality of the MOBLI score is similar to that of self-reported mobility 
      disability in the studied population. CONCLUSIONS: the 'objective' MOBLI index 
      has predictive validity as a continuous or dichotomised measure of the 
      physiological component of mobility limitation in older populations. Given its 
      empirical basis and face validity, predictive validity and responsiveness to 
      change, MOBLI should be considered for local validation and use in 
      epidemiological comparisons of older populations across countries or over longer 
      periods of time.
FAU - Melzer, David
AU  - Melzer D
AD  - Department of Public Health and Primary Care, University of Cambridge, Cambridge, 
      UK. dm214@medschl.cam.ac.uk
FAU - Lan, Tzuo-Yun
AU  - Lan TY
FAU - Guralnik, Jack M
AU  - Guralnik JM
LA  - eng
PT  - Journal Article
PL  - England
TA  - Age Ageing
JT  - Age and ageing
JID - 0375655
SB  - IM
MH  - Activities of Daily Living/*classification
MH  - Aged
MH  - Aged, 80 and over
MH  - Boston
MH  - Cohort Studies
MH  - Connecticut
MH  - *Disability Evaluation
MH  - Female
MH  - Geriatric Assessment/*statistics & numerical data
MH  - Health Surveys
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Musculoskeletal Diseases/*mortality
MH  - Proportional Hazards Models
MH  - Reproducibility of Results
MH  - Survival Analysis
MH  - *Walking
EDAT- 2003/11/06 05:00
MHDA- 2004/04/22 05:00
CRDT- 2003/11/06 05:00
PHST- 2003/11/06 05:00 [pubmed]
PHST- 2004/04/22 05:00 [medline]
PHST- 2003/11/06 05:00 [entrez]
AID - 10.1093/ageing/afg107 [doi]
PST - ppublish
SO  - Age Ageing. 2003 Nov;32(6):619-25. doi: 10.1093/ageing/afg107.