PMID- 14600627
OWN - NLM
STAT- MEDLINE
DCOM- 20040311
LR  - 20190917
IS  - 1049-2275 (Print)
IS  - 1049-2275 (Linking)
VI  - 14
IP  - 6
DP  - 2003 Nov
TI  - The role of nerve growth factor and brain-derived neurotrophic factor in inferior 
      alveolar nerve regeneration in distraction osteogenesis.
PG  - 859-65
AB  - Distraction osteogenesis (DO) has become the mainstay of treatment of mandibular 
      hypoplasias. Despite the clinical acceptance of the technique in the last decade, 
      little is known of the biological mechanism of bone and soft tissue regeneration. 
      The biological response of peripheral nerves to distraction has not been well 
      documented. This study examined the role of two neurotrophic molecules, nerve 
      growth factor (NGF) and brain-derived neurotrophic factor (BDNF), in DO on nerve 
      regeneration of the inferior alveolar nerve (IAN) in an ovine mandible model. 
      Twelve animals were randomly divided into three groups and distracted at 5, 10, 
      and 15 days using a mandibular osteotomy and uniaxial external distractor. The 
      mental nerves and the IAN from the distracted site were harvested at the end of 
      the distraction period and examined for the presence of NGF and BDNF using 
      immunohistochemistry. Nerve growth factor expression was increased at both sites, 
      whereas BDNF was only expressed at the mental nerve on the distracted side. Nerve 
      growth factor and BDNF are involved in the response of the peripheral nerves to 
      injury. Mechanical force applied to the IAN by distraction may lead to detachment 
      of Schwann cells from their axons, leading to segmental degeneration. The 
      resulting myelin sheath debris may serve as a trigger for higher expression of 
      NGF and BDNF, facilitating Schwann cell proliferation and remyelination of the 
      affected segment. Distraction of the mandible may serve as a source of subacute 
      injury to the IAN and influence NGF and BDNF.
FAU - Farhadieh, Rostcam D
AU  - Farhadieh RD
AD  - Orthopaedic Research Laboratory, Division of Surgery, University of New South 
      Wales, Sydney, Australia.
FAU - Nicklin, Sean
AU  - Nicklin S
FAU - Yu, Yan
AU  - Yu Y
FAU - Gianoutsos, Mark P
AU  - Gianoutsos MP
FAU - Walsh, William R
AU  - Walsh WR
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Craniofac Surg
JT  - The Journal of craniofacial surgery
JID - 9010410
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 9061-61-4 (Nerve Growth Factor)
MH  - Animals
MH  - Axons/ultrastructure
MH  - Brain-Derived Neurotrophic Factor/*analysis/physiology
MH  - Cell Division/physiology
MH  - Chin/innervation
MH  - Double-Blind Method
MH  - Endothelium, Vascular/pathology
MH  - Immunohistochemistry
MH  - Mandible/innervation/surgery
MH  - Mandibular Nerve/pathology/*physiopathology
MH  - Models, Animal
MH  - Myelin Sheath/physiology
MH  - Nerve Degeneration/pathology/physiopathology
MH  - Nerve Growth Factor/*analysis/physiology
MH  - Nerve Regeneration/*physiology
MH  - *Osteogenesis, Distraction/instrumentation
MH  - Osteotomy
MH  - Random Allocation
MH  - Schwann Cells/pathology
MH  - Sheep
MH  - Time Factors
EDAT- 2003/11/06 05:00
MHDA- 2004/03/12 05:00
CRDT- 2003/11/06 05:00
PHST- 2003/11/06 05:00 [pubmed]
PHST- 2004/03/12 05:00 [medline]
PHST- 2003/11/06 05:00 [entrez]
AID - 10.1097/00001665-200311000-00007 [doi]
PST - ppublish
SO  - J Craniofac Surg. 2003 Nov;14(6):859-65. doi: 10.1097/00001665-200311000-00007.