PMID- 14602231
OWN - NLM
STAT- MEDLINE
DCOM- 20040813
LR  - 20211216
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 64
IP  - 11
DP  - 2003 Nov
TI  - Mobilizing dendritic cells for tolerance by engagement of immune inhibitory 
      receptors for HLA-G.
PG  - 1025-32
AB  - The presence of dendritic cells (DC) in the maternal decidua has pointed to a 
      biologic role of antigen-presenting cell in maternal-fetal interaction. The 
      expression of immune inhibitory receptors on DC opens the intriguing possibility 
      that these types of receptors are directly involved in maturation/activation of 
      DC and modulate their function. We show that the triggering of the murine 
      inhibitory receptor paired immunoglobulin-like receptor-B by cross-linking or by 
      human leukocyte antigen (HLA)-G tetramer resulted in the modulation of DC 
      function and prolongation of allogeneic graft survival. In addition, we found 
      that the engagement of human inhibitory receptor ILT4 by its natural ligand, 
      HLA-G, alters maturation of human DC. In this study, we examined the mechanisms 
      for the modulation of antigen-presenting cells by HLA-G. These findings have 
      established an important link between HLA-G and immune inhibitory receptor 
      regulation in vivo and in vitro, thereby placing HLA-G in the inhibitory pathway.
FAU - Liang, Siyuan
AU  - Liang S
AD  - Institute of Molecular Medicine and Genetics, Medical College of Georgia, 
      Augusta, GA 30912, USA.
FAU - Horuzsko, Anatolij
AU  - Horuzsko A
LA  - eng
GR  - R01 AI055923/AI/NIAID NIH HHS/United States
GR  - AI 055923/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-G Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (LILRB2 protein, human)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (NF-kappa B)
RN  - 0 (Pirb protein, mouse)
RN  - 0 (Receptors, Immunologic)
RN  - 147205-72-9 (CD40 Ligand)
RN  - EC 3.1.3.48 (PTPN6 protein, human)
RN  - EC 3.1.3.48 (Protein Tyrosine Phosphatase, Non-Receptor Type 6)
RN  - EC 3.1.3.48 (Protein Tyrosine Phosphatases)
RN  - EC 3.1.3.48 (Ptpn6 protein, mouse)
SB  - IM
MH  - Animals
MH  - Blotting, Western
MH  - Bone Marrow Cells/immunology/metabolism
MH  - CD40 Ligand/metabolism
MH  - Cell Differentiation
MH  - Cell Nucleus/metabolism
MH  - Dendritic Cells/*immunology
MH  - Female
MH  - Graft Survival/*immunology
MH  - HLA Antigens/*immunology
MH  - HLA-G Antigens
MH  - Histocompatibility Antigens Class I/*immunology
MH  - Humans
MH  - *Immune Tolerance
MH  - Intracellular Signaling Peptides and Proteins
MH  - Male
MH  - Membrane Glycoproteins
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Inbred CBA
MH  - NF-kappa B/metabolism
MH  - Phosphorylation
MH  - Protein Tyrosine Phosphatase, Non-Receptor Type 6
MH  - Protein Tyrosine Phosphatases/metabolism
MH  - Receptors, Immunologic/immunology/metabolism
MH  - Skin Transplantation/*immunology
MH  - Specific Pathogen-Free Organisms
MH  - T-Lymphocyte Subsets/immunology
EDAT- 2003/11/07 05:00
MHDA- 2004/08/17 10:00
CRDT- 2003/11/07 05:00
PHST- 2003/11/07 05:00 [pubmed]
PHST- 2004/08/17 10:00 [medline]
PHST- 2003/11/07 05:00 [entrez]
AID - S0198885903005366 [pii]
AID - 10.1016/j.humimm.2003.08.348 [doi]
PST - ppublish
SO  - Hum Immunol. 2003 Nov;64(11):1025-32. doi: 10.1016/j.humimm.2003.08.348.