PMID- 14602239
OWN - NLM
STAT- MEDLINE
DCOM- 20040813
LR  - 20201215
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 64
IP  - 11
DP  - 2003 Nov
TI  - Altered expression of nonclassical HLA class Ib antigens in human renal cell 
      carcinoma and its association with impaired immune response.
PG  - 1081-92
AB  - An optimal antitumoral immune response requires the activation of both CD8(+) and 
      CD4(+) T lymphocytes by the peptide antigen presentation via the human leukocyte 
      antigen (HLA) class I and class II molecules, respectively. Downregulation or 
      loss of HLA molecules has been found in human renal cell carcinoma (RCC) and 
      provides a strategy of these tumors to evade T-cell mediated immunosurveillance. 
      In addition, a tumor-specific upregulation of HLA-G has been recently described 
      in RCC, which also leads to an impaired immune response. We here summarize the 
      frequency of the constitutive and/or interferon-gamma (IFN-gamma) inducible 
      expression of nonclassical HLA class Ib antigens in RCC cell lines, surgically 
      removed RCC lesions and normal kidney epithelium, the molecular characteristics 
      of HLA-G expression, and its role in immune recognition.
FAU - Bukur, Jurgen
AU  - Bukur J
AD  - Third Department of Internal Medicine, Johannes Gutenberg-University, Mainz, 
      Germany.
FAU - Malenica, Barbara
AU  - Malenica B
FAU - Huber, Christoph
AU  - Huber C
FAU - Seliger, Barbara
AU  - Seliger B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-G Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (RNA, Messenger)
RN  - 0 (Recombinant Proteins)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Antibodies, Monoclonal
MH  - Blotting, Southern
MH  - Blotting, Western
MH  - Carcinoma, Renal Cell/genetics/*immunology/metabolism
MH  - Flow Cytometry
MH  - Gene Expression Regulation, Neoplastic
MH  - HLA Antigens/biosynthesis/*genetics/*immunology
MH  - HLA-G Antigens
MH  - Histocompatibility Antigens Class I/biosynthesis/*genetics/*immunology
MH  - Humans
MH  - Interferon-gamma/pharmacology
MH  - Kidney Neoplasms/genetics/*immunology/metabolism
MH  - Killer Cells, Natural/immunology
MH  - RNA, Messenger/biosynthesis/genetics
MH  - Recombinant Proteins
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - T-Lymphocytes, Cytotoxic/immunology
MH  - Tumor Cells, Cultured
MH  - Up-Regulation
EDAT- 2003/11/07 05:00
MHDA- 2004/08/17 10:00
CRDT- 2003/11/07 05:00
PHST- 2003/11/07 05:00 [pubmed]
PHST- 2004/08/17 10:00 [medline]
PHST- 2003/11/07 05:00 [entrez]
AID - S019888590300538X [pii]
AID - 10.1016/j.humimm.2003.08.350 [doi]
PST - ppublish
SO  - Hum Immunol. 2003 Nov;64(11):1081-92. doi: 10.1016/j.humimm.2003.08.350.