PMID- 14602731
OWN - NLM
STAT- MEDLINE
DCOM- 20031209
LR  - 20220408
IS  - 0021-972X (Print)
IS  - 0021-972X (Linking)
VI  - 88
IP  - 11
DP  - 2003 Nov
TI  - Ketosis-prone diabetes: dissection of a heterogeneous syndrome using an 
      immunogenetic and beta-cell functional classification, prospective analysis, and 
      clinical outcomes.
PG  - 5090-8
AB  - Ketosis-prone diabetes is heterogeneous. Its causes could include novel beta-cell 
      functional defects. To characterize such defects, 103 patients with diabetic 
      ketoacidosis were evaluated for beta-cell autoimmunity and human leukocyte 
      antigen (HLA) class II alleles, with longitudinal measurements of beta-cell 
      function and biochemical and clinical parameters. They were classified into four 
      A beta groups, based on the presence of glutamic acid decarboxylase (GAD)65, 
      GAD67, or IA-2 autoantibodies (A+ or A-) and beta-cell functional reserve (beta+ 
      or beta-). The group distribution was: 18 A+beta-, 23 A-beta-, 11 A+beta+, and 51 
      A-beta+. Collectively, the two beta- groups differed from the two beta+ groups in 
      earlier onset and longer duration of diabetes, lower body mass index, less 
      glycemic improvement, and persistent insulin requirement. HLA class II genotyping 
      showed that the A-beta- group differed from the A+beta- group in having lower 
      frequencies of two alleles strongly associated with autoimmune type 1 diabetes 
      susceptibility: DQA*03 and DQB1*02. Similarly, the A-beta+ group differed from 
      the A+beta+ group in having a lower frequency of DQB1*02. Ketosis-prone diabetes 
      comprises at least four etiologically distinct syndromes separable by 
      autoantibody status, HLA genotype, and beta-cell functional reserve. Novel, 
      nonautoimmune causes of beta-cell dysfunction are likely to underlie the A-beta+ 
      and A-beta- syndromes.
FAU - Maldonado, Mario
AU  - Maldonado M
AD  - Division of Endocrinology, Department of Medicine, Baylor College of Medicine, 
      Houston, Texas 77030, USA.
FAU - Hampe, Christiane S
AU  - Hampe CS
FAU - Gaur, Lakshmi K
AU  - Gaur LK
FAU - D'Amico, Susana
AU  - D'Amico S
FAU - Iyer, Dinakar
AU  - Iyer D
FAU - Hammerle, Lisa P
AU  - Hammerle LP
FAU - Bolgiano, Douglas
AU  - Bolgiano D
FAU - Rodriguez, Lucille
AU  - Rodriguez L
FAU - Rajan, Arun
AU  - Rajan A
FAU - Lernmark, Ake
AU  - Lernmark A
FAU - Balasubramanyam, Ashok
AU  - Balasubramanyam A
LA  - eng
GR  - R01 DK026190/DK/NIDDK NIH HHS/United States
GR  - DK26190/DK/NIDDK NIH HHS/United States
GR  - DK53004/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (Autoantibodies)
RN  - 0 (Blood Glucose)
RN  - 0 (Isoenzymes)
RN  - EC 4.1.1.15 (Glutamate Decarboxylase)
RN  - EC 4.1.1.15 (glutamate decarboxylase 1)
RN  - EC 4.1.1.15 (glutamate decarboxylase 2)
SB  - IM
CIN - J Clin Endocrinol Metab. 2003 Nov;88(11):5087-9. PMID: 14602730
MH  - Adolescent
MH  - Adult
MH  - Autoantibodies/blood
MH  - Blood Glucose
MH  - Diabetes Mellitus, Type 1/*classification/ethnology/genetics/immunology
MH  - Diabetes Mellitus, Type 2/*classification/ethnology/genetics/immunology
MH  - Diabetic Ketoacidosis/*classification/ethnology/genetics/immunology
MH  - Ethnicity
MH  - Female
MH  - Gene Frequency
MH  - Glutamate Decarboxylase/immunology
MH  - Histocompatibility Testing
MH  - Humans
MH  - Islets of Langerhans/*immunology
MH  - Isoenzymes/immunology
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
EDAT- 2003/11/07 05:00
MHDA- 2003/12/10 05:00
CRDT- 2003/11/07 05:00
PHST- 2003/11/07 05:00 [pubmed]
PHST- 2003/12/10 05:00 [medline]
PHST- 2003/11/07 05:00 [entrez]
AID - 10.1210/jc.2003-030180 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 2003 Nov;88(11):5090-8. doi: 10.1210/jc.2003-030180.