PMID- 14604757
OWN - NLM
STAT- MEDLINE
DCOM- 20040219
LR  - 20190901
IS  - 0165-3806 (Print)
IS  - 0165-3806 (Linking)
VI  - 145
IP  - 2
DP  - 2003 Nov 12
TI  - In utero development of central ANG-stimulated pressor response and hypothalamic 
      fos expression.
PG  - 169-76
AB  - Central renin-angiotensin system (RAS) is as important as the peripheral RAS in 
      the control of the cardiovascular homeostasis in the adult. However, previous 
      fetal studies on angiotensin II (ANG II)-induced cardiovascular responses focused 
      exclusively on the peripheral side. Thus, few data exist characterizing the in 
      utero development of central angiotensin-mediated pressor responses. The present 
      study determined cardiovascular responses to central application of ANG II in the 
      chronically prepared near-term ovine fetus, and determined the action sites 
      marked by c-fos expression in the fetal hypothalamus following 
      intracerebroventricular (icv) injection of ANG II in utero. ANG II significantly 
      increased fetal systolic, diastolic, and mean arterial pressure (MAP) within 5 
      min after injection of this peptide into the brain. Adjusted fetal MAP against 
      amniotic pressure was also increased by icv ANG II, associated with increased 
      c-fos in the central putative cardiovascular area--the paraventricular nuclei 
      (PVN). Application of ANG II also induced intense c-fos expression in the 
      supraoptic nuclei (SON), accompanied by a significant increase of fetal plasma 
      vasopressin (AVP) levels, while maternal blood pressure (BP) and plasma AVP 
      concentration were not changed. These results indicate that the central ANG 
      II-mediated pressor response is functional at the last third of gestation, acting 
      at the sites consistent with the cardiovascular neural network in the 
      hypothalamus.
FAU - Xu, Zhice
AU  - Xu Z
AD  - Department of Obstetrics and Gynecology and Division of Vascular Surgery, 
      Harbor-UCLA Medical Center and Research and Education Institute, 1124 West Carson 
      Street, RB-1, Torrance, CA 90502, USA. zxu@gcrc.rei.edu
FAU - Shi, Lijun
AU  - Shi L
FAU - Hu, Fang
AU  - Hu F
FAU - White, Rodney
AU  - White R
FAU - Stewart, Lauren
AU  - Stewart L
FAU - Yao, Jiaming
AU  - Yao J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Brain Res Dev Brain Res
JT  - Brain research. Developmental brain research
JID - 8908639
RN  - 0 (Proto-Oncogene Proteins c-fos)
RN  - 11128-99-7 (Angiotensin II)
RN  - 113-79-1 (Arginine Vasopressin)
SB  - IM
MH  - Angiotensin II/*metabolism/pharmacology
MH  - Animals
MH  - Arginine Vasopressin/blood
MH  - Blood Pressure/drug effects/*physiology
MH  - Female
MH  - Fetus/embryology/*physiology
MH  - Hypothalamus/drug effects/embryology/*metabolism
MH  - Immunohistochemistry
MH  - Injections, Intraventricular
MH  - Nerve Net/drug effects/embryology/metabolism
MH  - Neurons/drug effects/metabolism
MH  - Paraventricular Hypothalamic Nucleus/drug effects/metabolism
MH  - Pregnancy
MH  - Proto-Oncogene Proteins c-fos/drug effects/*metabolism
MH  - Sheep
MH  - Supraoptic Nucleus/drug effects/metabolism
EDAT- 2003/11/08 05:00
MHDA- 2004/02/20 05:00
CRDT- 2003/11/08 05:00
PHST- 2003/11/08 05:00 [pubmed]
PHST- 2004/02/20 05:00 [medline]
PHST- 2003/11/08 05:00 [entrez]
AID - S0165380603002268 [pii]
AID - 10.1016/s0165-3806(03)00226-8 [doi]
PST - ppublish
SO  - Brain Res Dev Brain Res. 2003 Nov 12;145(2):169-76. doi: 
      10.1016/s0165-3806(03)00226-8.