PMID- 14605493
OWN - NLM
STAT- MEDLINE
DCOM- 20040618
LR  - 20171101
IS  - 1422-6405 (Print)
IS  - 1422-6405 (Linking)
VI  - 175
IP  - 1
DP  - 2003
TI  - Types of programmed cell death: two variants expressed by neonatal murine 
      hepatocytes.
PG  - 34-42
AB  - Neonatal livers examined with the terminal transferase-mediated dUTP nick end 
      labeling (TUNEL) method contained numerous positive cells. Although the majority 
      of dying cells are either hematopoietic cells including erythroids and 
      granulocytes or macrophages, a few hepatocytes were also positive. As for the 
      ultrastructural features of these dying hepatocytes, two different types, type I 
      and II, could be identified. The early features of type I appeared in the 
      cytoplasm, which was characterized by dilated rough endoplasmic reticulum, and 
      the cell fragments displayed a round, foamy appearance. Type II was characterized 
      by nuclear compaction and margination of heterochromatin resulting in the 
      formation of sharply circumscribed masses, followed by the condensation of the 
      cytoplasm. The cell death of type I, characterized by the formation of massive 
      vacuolization of the endoplasmic reticulum, corresponds to cytoplasmic type 
      degeneration or nonapoptotic death, while that of type II corresponds to nuclear 
      type cell death or classical apoptotic death. In the two types of programmed cell 
      death, the incidence of nonapoptotic cell death was much higher than that of 
      classical apoptosis in neonatal murine hepatocytes.
CI  - Copyright 2003 S. Karger AG, Basel
FAU - Sasaki, K
AU  - Sasaki K
AD  - Department of Anatomy, Kawasaki Medical School, Kurashiki, Japan. 
      kazus@med.kawasaki-m.ac.jp
FAU - Sonoda, Y
AU  - Sonoda Y
FAU - Kumano, I
AU  - Kumano I
FAU - Suda, M
AU  - Suda M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Cells Tissues Organs
JT  - Cells, tissues, organs
JID - 100883360
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Animals, Newborn
MH  - Apoptosis/*physiology
MH  - Cell Nucleus/ultrastructure
MH  - Cytoplasm/ultrastructure
MH  - Hepatocytes/*cytology/ultrastructure
MH  - In Situ Nick-End Labeling
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Microscopy, Electron
MH  - Vacuoles/ultrastructure
EDAT- 2003/11/08 05:00
MHDA- 2004/06/24 05:00
CRDT- 2003/11/08 05:00
PHST- 2003/07/03 00:00 [accepted]
PHST- 2003/11/08 05:00 [pubmed]
PHST- 2004/06/24 05:00 [medline]
PHST- 2003/11/08 05:00 [entrez]
AID - 73435 [pii]
AID - 10.1159/000073435 [doi]
PST - ppublish
SO  - Cells Tissues Organs. 2003;175(1):34-42. doi: 10.1159/000073435.