PMID- 14606632 OWN - NLM STAT- MEDLINE DCOM- 20040610 LR - 20220716 IS - 0967-3849 (Print) IS - 0967-3849 (Linking) VI - 11 IP - 7 DP - 2003 TI - Chromosomal localization of six repeated DNA sequences among species of Microtus (Rodentia). PG - 705-13 AB - C-banding and fluorescence in situ hybridization (FISH) document the distribution of constitutive heterochromatin and six highly repeated DNA families (MSAT2570, MSAT21, MSAT160, MS2, MS4 and STR47) in the chromosomes of nine species of Microtus (M. chrotorrhinus, M. rossiaemeridionalis, M. arvalis, M. ilaeus, M. transcaspicus, M. cabrerae, M. pennsylvanicus, M. miurus and M. ochrogaster). Autosomal heterochromatin is largely centromeric and contains different repeated families in different species. Similarly, large C-band positive blocks on the sex chromosomes of four species contain different repeated DNAs. This interspecific variation in the chromosomal distribution and copy number of the repeats suggests that a common ancestor to modern species contained most of the repetitive families, and that descendant species selectively amplified or deleted different repeats on different chromosomes. FAU - Modi, William S AU - Modi WS AD - Basic Research Program, SAIC Frederick, National Cancer Institute at Frederick, Frederick, MD 21702, USA. modi@ncifcrf.gov FAU - Serdyukova, Natalya A AU - Serdyukova NA FAU - Vorobieva, Nadezhda V AU - Vorobieva NV FAU - Graphodatsky, Alexander S AU - Graphodatsky AS LA - eng GR - N01-CO-124000/CO/NCI NIH HHS/United States PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Research Support, U.S. Gov't, P.H.S. PL - Netherlands TA - Chromosome Res JT - Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology JID - 9313452 RN - 0 (Heterochromatin) RN - 9007-49-2 (DNA) SB - IM MH - Animals MH - Arvicolinae/*genetics MH - Chromosome Banding MH - *Chromosome Mapping MH - Chromosomes/*ultrastructure MH - DNA/*ultrastructure MH - Fibroblasts/metabolism MH - Gene Deletion MH - Heterochromatin/genetics/ultrastructure MH - In Situ Hybridization, Fluorescence MH - Nucleic Acid Hybridization MH - *Repetitive Sequences, Nucleic Acid MH - Species Specificity EDAT- 2003/11/11 05:00 MHDA- 2004/06/21 10:00 CRDT- 2003/11/11 05:00 PHST- 2003/11/11 05:00 [pubmed] PHST- 2004/06/21 10:00 [medline] PHST- 2003/11/11 05:00 [entrez] AID - 10.1023/a:1025922813756 [doi] PST - ppublish SO - Chromosome Res. 2003;11(7):705-13. doi: 10.1023/a:1025922813756.