PMID- 14608199
OWN - NLM
STAT- MEDLINE
DCOM- 20031203
LR  - 20190917
IS  - 1077-4114 (Print)
IS  - 1077-4114 (Linking)
VI  - 25
IP  - 11
DP  - 2003 Nov
TI  - Role of transforming growth factor-beta 1 gene polymorphisms in childhood 
      idiopathic thrombocytopenic purpura.
PG  - 885-9
AB  - PURPOSE: To investigate whether transforming growth factor-beta 1 (TGF-beta 1) 
      gene polymorphisms have a role in the development, clinical progress, and 
      treatment response in children with idiopathic thrombocytopenic purpura (ITP). 
      PATIENTS AND METHODS: Thirty-five children with acute ITP, 40 children with 
      chronic ITP, and 97 healthy children were enrolled. After genomic DNA was 
      extracted, TGF-beta 1 gene 509 (C-->T), codon 25 (Arg-->Pro), and codon 10 
      (Leu-->Pro) polymorphisms were studied using a coupled polymerase chain 
      reaction-restriction enzyme digestion method. RESULTS: The genotype and allele 
      frequencies of TGF-beta 1 polymorphisms between acute ITP, chronic ITP, and 
      control group did not differ significantly. No significant association was found 
      between TGF-beta 1 polymorphisms and therapy response. CONCLUSIONS: These results 
      demonstrate that the frequency of TGF-beta1 gene 509 (C-->T), codon 25 
      (Arg-->Pro), and codon 10 (Leu-->Pro) polymorphisms and alleles do not play a 
      role as a genetic risk factor in the development and clinical progress of ITP. 
      Different results may be obtained with further studies involving larger patient 
      populations and other TGF-beta 1 gene polymorphisms.
FAU - Atabay, Berna
AU  - Atabay B
AD  - Department of Pediatric Hematology, Dokuz Eylul Faculty of Medicine, Izmir, 
      Turkey.
FAU - Oren, Hale
AU  - Oren H
FAU - Irken, Gulersu
AU  - Irken G
FAU - Kizildag, Sefa
AU  - Kizildag S
FAU - Tunali, Sunay
AU  - Tunali S
FAU - Turker, Meral
AU  - Turker M
FAU - Yilmaz, Sebnem
AU  - Yilmaz S
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Pediatr Hematol Oncol
JT  - Journal of pediatric hematology/oncology
JID - 9505928
RN  - 0 (Codon)
RN  - 0 (TGFB1 protein, human)
RN  - 0 (Transforming Growth Factor beta)
RN  - 0 (Transforming Growth Factor beta1)
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - Codon
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Infant
MH  - Male
MH  - *Polymorphism, Genetic
MH  - Purpura, Thrombocytopenic, Idiopathic/etiology/*genetics
MH  - Risk Factors
MH  - Transforming Growth Factor beta/*genetics
MH  - Transforming Growth Factor beta1
EDAT- 2003/11/11 05:00
MHDA- 2003/12/04 05:00
CRDT- 2003/11/11 05:00
PHST- 2003/11/11 05:00 [pubmed]
PHST- 2003/12/04 05:00 [medline]
PHST- 2003/11/11 05:00 [entrez]
AID - 10.1097/00043426-200311000-00012 [doi]
PST - ppublish
SO  - J Pediatr Hematol Oncol. 2003 Nov;25(11):885-9. doi: 
      10.1097/00043426-200311000-00012.