PMID- 14609036
OWN - NLM
STAT- MEDLINE
DCOM- 20040106
LR  - 20150901
IS  - 2072-0939 (Print)
IS  - 2072-0939 (Linking)
VI  - 26
IP  - 8
DP  - 2003 Aug
TI  - Prediction of elevated cord blood IgE levels by maternal IgE levels, and the 
      neonate's gender and gestational age.
PG  - 561-9
AB  - BACKGROUND: Elevation of cord blood immunoglobulin E (IgE) is used to predict 
      childhood atopy. In an effort to catch such problems at an earlier time, we 
      sought to identify the impact of parental atopy as well as gestational age, the 
      baby's gender, and the season of delivery on cord blood IgE levels. METHODS: The 
      allergic history of parents was collected during pregnancy. Blood samples from 
      parents were collected in the third trimester. Cord blood was collected 
      immediately after birth. Total and specific IgE levels were determined using the 
      Pharmacia CAP system. RESULTS: In total, 437 core family blood samples were 
      collected. Male babies had a significantly higher IgE level (0.535 +/- 0.898 vs. 
      0.369 +/- 0.565 KU/L, p = 0.021) and a higher frequency of IgE > or = 1.0 KU/L 
      (14.6% vs. 7.5%, p = 0.018) compared to female babies. A cyclic trend in higher 
      cord blood IgE levels was found in babies born in early summer and early winter. 
      Multiple logistic regression analyses revealed that elevation of cord blood IgE 
      levels could be predicted by higher maternal IgE levels (odds ratio [OR] = 6.35; 
      p = 0.000), male baby gender (OR = 2.31; p = 0.021), and increases in gestational 
      age by 1 week (OR = 1.34; p = 0.039). In contrast, neither the allergic history 
      of parents nor elevation of paternal IgE levels could be correlated with elevated 
      cord blood IgE levels of neonates. CONCLUSION: The baby's gender and gestational 
      age, and maternal IgE levels influence cord blood IgE levels. Avoiding allergens 
      and decreasing allergic activities during pregnancy may be the most important 
      means of preventing the fetus from having allergic sensitization.
FAU - Liu, Chieh-An
AU  - Liu CA
AD  - Department of Pediatrics, Chang Gung Children's Hospital, Kaoshiung, Taiwan, ROC.
FAU - Wang, Chih-Lu
AU  - Wang CL
FAU - Chuang, Hau
AU  - Chuang H
FAU - Ou, Chia-Yu
AU  - Ou CY
FAU - Hsu, Te-Yao
AU  - Hsu TY
FAU - Yang, Kuender D
AU  - Yang KD
LA  - eng
PT  - Journal Article
PL  - China (Republic : 1949- )
TA  - Chang Gung Med J
JT  - Chang Gung medical journal
JID - 101088034
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Female
MH  - Fetal Blood/*immunology
MH  - Gestational Age
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Infant, Newborn
MH  - Logistic Models
MH  - Male
MH  - Pregnancy/*immunology
MH  - Seasons
MH  - Sensitivity and Specificity
MH  - Sex Factors
EDAT- 2003/11/12 05:00
MHDA- 2004/01/07 05:00
CRDT- 2003/11/12 05:00
PHST- 2003/11/12 05:00 [pubmed]
PHST- 2004/01/07 05:00 [medline]
PHST- 2003/11/12 05:00 [entrez]
AID - 2608/260803 [pii]
PST - ppublish
SO  - Chang Gung Med J. 2003 Aug;26(8):561-9.