PMID- 14609876
OWN - NLM
STAT- MEDLINE
DCOM- 20040105
LR  - 20081121
IS  - 0004-0010 (Print)
IS  - 0004-0010 (Linking)
VI  - 138
IP  - 11
DP  - 2003 Nov
TI  - Expression of transforming growth factor beta1 in patients with and without 
      previous abdominal surgery.
PG  - 1249-52
AB  - HYPOTHESIS: Transforming growth factor beta1 (TGF-beta1) plays an important role 
      in the formation of adhesions after abdominal operations. DESIGN: Prospective, 
      observational study. SETTING: University-based, tertiary referral center. 
      PATIENTS: Patients undergoing elective open abdominal operations were recruited 
      and divided into 2 groups. Twenty-two patients with a history of abdominal 
      surgery were designated as study patients, and 10 patients with no history of 
      abdominal surgery served as controls. INTERVENTIONS: Samples of normal 
      peritoneum, peritoneal scar tissues, and serum were obtained from all patients at 
      the time of surgery. MAIN OUTCOME MEASURES: Samples were assayed for total 
      TGF-beta1 expression using an enzyme-linked immunosorbent assay. RESULTS: Scar 
      tissues expressed significantly greater amounts of TGF-beta1 (0.47 pg/ micro L) 
      compared with normal peritoneal tissue from both study patients (0.29 pg/ micro 
      L; P =.03) and controls (0.17 pg/ micro L; P =.002). Serum TGF-beta1 levels were 
      also higher in study patients (1.71 pg/ micro L) compared with controls (1.22 pg/ 
      micro L; P =.02). Neither adhesion nor serum TGF-beta1 expression correlated with 
      time since last operation, total number of previous operations, or severity of 
      intra-abdominal adhesions. CONCLUSION: These results suggest that TGF-beta1 may 
      play an important role in human peritoneal adhesion formation.
FAU - Hobson, Kristina G
AU  - Hobson KG
AD  - Department of Surgery, University of California-Davis Medical Center, USA.
FAU - DeWing, Michelle
AU  - DeWing M
FAU - Ho, Hung S
AU  - Ho HS
FAU - Wolfe, Bruce M
AU  - Wolfe BM
FAU - Cho, Kiho
AU  - Cho K
FAU - Greenhalgh, David G
AU  - Greenhalgh DG
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Arch Surg
JT  - Archives of surgery (Chicago, Ill. : 1960)
JID - 9716528
RN  - 0 (TGFB1 protein, human)
RN  - 0 (Transforming Growth Factor beta)
RN  - 0 (Transforming Growth Factor beta1)
SB  - IM
MH  - Abdominal Cavity/*physiology/physiopathology/surgery
MH  - Cicatrix/*metabolism/physiopathology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Peritoneum/*metabolism/physiopathology/surgery
MH  - Prospective Studies
MH  - Surgical Procedures, Operative/*adverse effects
MH  - Tissue Adhesions/etiology/*metabolism
MH  - Transforming Growth Factor beta/*biosynthesis
MH  - Transforming Growth Factor beta1
EDAT- 2003/11/12 05:00
MHDA- 2004/01/06 05:00
CRDT- 2003/11/12 05:00
PHST- 2003/11/12 05:00 [pubmed]
PHST- 2004/01/06 05:00 [medline]
PHST- 2003/11/12 05:00 [entrez]
AID - 138/11/1249 [pii]
AID - 10.1001/archsurg.138.11.1249 [doi]
PST - ppublish
SO  - Arch Surg. 2003 Nov;138(11):1249-52. doi: 10.1001/archsurg.138.11.1249.