PMID- 14614600
OWN - NLM
STAT- MEDLINE
DCOM- 20040423
LR  - 20151119
IS  - 0944-1174 (Print)
IS  - 0944-1174 (Linking)
VI  - 38
IP  - 10
DP  - 2003
TI  - Influence of anti-ulcer drugs used in Japan on the result of (13)C-urea breath 
      test for the diagnosis of Helicobacter pylori infection.
PG  - 937-41
AB  - BACKGROUND: The (13)C-urea breath test (UBT) is a simple breath test for the 
      diagnosis of Helicobacter pylori infection, but several factors have been 
      reported to affect the results of this test. In this study, the effects of the 
      antiulcer drugs used in Japan on the results of UBT were determined. METHODS: The 
      subjects of the study were 64 adult volunteers who tested positive for H. pylori 
      infection by the serum antibody method. Eight classes of anti-ulcer drugs used in 
      Japan were administered at their usual doses to these subjects: lansoprazole, a 
      proton pump inhibitor (PPI); nizatidine, an H(2)-receptor antagonist (H(2)RA); 
      and polaprezinc, ecabet sodium, rebamipide, teprenone, cetraxate hydrochloride, 
      and sucralfate, all mucoprotective agents. The study drugs were randomized for 
      administration to the subjects, and each of the drugs was administered for 14 
      consecutive days. The UBT was performed on days 0, 14, and 21. RESULTS: The mean 
      Delta(13)C per thousand in the lansoprazole group was significantly decreased on 
      day 14, to below 10 per thousand, in 4 of 16 subjects, and in 1 of the 4 
      subjects, the test result was negative, with the Delta(13)C per thousand falling 
      to 1.7 per thousand. The value returned to baseline 1 week after the 
      discontinuation of lansoprazole. The other drugs administered had no significant 
      effect on the result of the UBT, except that the mean Delta(13)C per thousand 
      showed a tendency to decrease after the administration of ecabet sodium and 
      rebamipide. CONCLUSIONS: Administration of a PPI may produce a false-negative UBT 
      result, while other anti-ulcer drugs, for the most part, have little effect on 
      the result of the UBT when used alone. The (13)C-urea breath test (UBT) is a 
      simple test for the diagnosis of Helicobacter pylori infection, but several 
      factors have been reported to affect the results of this test. In this study, the 
      effects of the anti-ulcer drugs used in Japan on the results of the UBT were 
      determined.
FAU - Murakami, Kazunari
AU  - Murakami K
AD  - Second Department of Internal Medicine, Oita Medical University, 1-1 Hasama, 
      879-5593 Oita, Japan.
FAU - Sato, Ryugo
AU  - Sato R
FAU - Okimoto, Tadayoshi
AU  - Okimoto T
FAU - Watanabe, Koichiro
AU  - Watanabe K
FAU - Nasu, Masaru
AU  - Nasu M
FAU - Fujioka, Toshio
AU  - Fujioka T
FAU - Kodama, Masaaki
AU  - Kodama M
FAU - Kagawa, Jiro
AU  - Kagawa J
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - Japan
TA  - J Gastroenterol
JT  - Journal of gastroenterology
JID - 9430794
RN  - 0 (2-Pyridinylmethylsulfinylbenzimidazoles)
RN  - 0 (Anti-Ulcer Agents)
RN  - 0 (Carbon Radioisotopes)
RN  - 0 (Histamine H2 Antagonists)
RN  - 0 (Proton Pump Inhibitors)
RN  - 0 (Proton Pumps)
RN  - 0K5C5T2QPG (Lansoprazole)
RN  - 8W8T17847W (Urea)
RN  - KG60484QX9 (Omeprazole)
RN  - P41PML4GHR (Nizatidine)
SB  - IM
MH  - 2-Pyridinylmethylsulfinylbenzimidazoles
MH  - Adult
MH  - Anti-Ulcer Agents/administration & dosage/*therapeutic use
MH  - Breath Tests
MH  - Carbon Radioisotopes/metabolism
MH  - Dose-Response Relationship, Drug
MH  - False Negative Reactions
MH  - Female
MH  - Helicobacter Infections/*diagnosis/*drug therapy/microbiology
MH  - Helicobacter pylori/*drug effects
MH  - Histamine H2 Antagonists/administration & dosage
MH  - Humans
MH  - Japan/epidemiology
MH  - Lansoprazole
MH  - Male
MH  - Middle Aged
MH  - Nizatidine/administration & dosage
MH  - Omeprazole/administration & dosage/*analogs & derivatives
MH  - Proton Pump Inhibitors
MH  - Proton Pumps/administration & dosage
MH  - Time Factors
MH  - Treatment Outcome
MH  - *Urea/metabolism
EDAT- 2003/11/14 05:00
MHDA- 2004/04/24 05:00
CRDT- 2003/11/14 05:00
PHST- 2002/09/20 00:00 [received]
PHST- 2003/03/14 00:00 [accepted]
PHST- 2003/11/14 05:00 [pubmed]
PHST- 2004/04/24 05:00 [medline]
PHST- 2003/11/14 05:00 [entrez]
AID - 10.1007/s00535-003-1176-x [doi]
PST - ppublish
SO  - J Gastroenterol. 2003;38(10):937-41. doi: 10.1007/s00535-003-1176-x.