PMID- 14614628
OWN - NLM
STAT- MEDLINE
DCOM- 20041013
LR  - 20181113
IS  - 0948-6143 (Print)
IS  - 0948-6143 (Linking)
VI  - 120
IP  - 6
DP  - 2003 Dec
TI  - Specific localization of epidermal-type fatty acid binding protein in dendritic 
      cells of splenic white pulp.
PG  - 465-73
AB  - Dendritic cells in the splenic white pulp of mice were intensely immunoreactive 
      for epidermal-type fatty acid binding protein (E-FABP). This specific 
      immunostaining revealed a clear difference in morphology between the dendritic 
      cells in the periarterial lymphoid sheath (PALS) and follicular dendritic cells 
      in the follicles in terms of cell sizes and process branching. No 
      immunoreactivity was detected in dendritic cells in the marginal zones and the 
      red pulp, although endothelial cells of almost all capillaries in the red pulp 
      were immunoreactive for E-FABP. After peritoneal injection of lipopolysaccharide, 
      the immunoreactive cells in PALS progressively enlarged and became rounded in 
      shape with a peak in size at 24 h postinjection and they eventually resumed the 
      dendritic form at 48 h postinjection. Within each of the enlarged immunoreactive 
      cell perikarya were included small immunonegative apoptotic cells, presumptive 
      lymphocytes. Taken together, E-FABP is useful as a marker for dendritic cells in 
      the splenic white pulp, and may be involved through combination with fatty acids 
      in antigen presentation and retention as well as in cytokine production.
FAU - Kitanaka, Noriko
AU  - Kitanaka N
AD  - Division of Histology, Department of Cell Biology, Graduate School of Medicine, 
      Tohoku University, 2-1 Seiryo-cho Aoba-ku, 980-8575 Sendai, Japan.
FAU - Owada, Yuji
AU  - Owada Y
FAU - Abdelwahab, Soha Abdelkawi
AU  - Abdelwahab SA
FAU - Iwasa, Hiroo
AU  - Iwasa H
FAU - Sakagami, Hiroyuki
AU  - Sakagami H
FAU - Watanabe, Makoto
AU  - Watanabe M
FAU - Spener, Friedrich
AU  - Spener F
FAU - Kondo, Hisatake
AU  - Kondo H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20031112
PL  - Germany
TA  - Histochem Cell Biol
JT  - Histochemistry and cell biology
JID - 9506663
RN  - 0 (Biomarkers)
RN  - 0 (Carrier Proteins)
RN  - 0 (Fabp5 protein, mouse)
RN  - 0 (Fatty Acid-Binding Proteins)
RN  - 0 (Neoplasm Proteins)
SB  - IM
MH  - Animals
MH  - Biomarkers
MH  - Carrier Proteins/*analysis
MH  - Dendritic Cells/*chemistry/immunology/ultrastructure
MH  - Fatty Acid-Binding Proteins
MH  - Immunohistochemistry
MH  - Mice
MH  - Mice, Knockout
MH  - Microscopy, Fluorescence
MH  - Microscopy, Immunoelectron
MH  - Neoplasm Proteins/*analysis
MH  - Phagocytosis
MH  - Spleen/*chemistry/cytology
EDAT- 2003/11/14 05:00
MHDA- 2004/10/14 09:00
CRDT- 2003/11/14 05:00
PHST- 2003/10/23 00:00 [accepted]
PHST- 2003/11/14 05:00 [pubmed]
PHST- 2004/10/14 09:00 [medline]
PHST- 2003/11/14 05:00 [entrez]
AID - 10.1007/s00418-003-0590-8 [doi]
PST - ppublish
SO  - Histochem Cell Biol. 2003 Dec;120(6):465-73. doi: 10.1007/s00418-003-0590-8. Epub 
      2003 Nov 12.