PMID- 14615042
OWN - NLM
STAT- MEDLINE
DCOM- 20040120
LR  - 20190701
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 352
IP  - 1
DP  - 2003 Nov 27
TI  - The role of -850 tumor necrosis factor-alpha and apolipoprotein E genetic 
      polymorphism in patients with Down's syndrome-related dementia.
PG  - 29-32
AB  - Down's syndrome (DS) is a disease with a complex etiology. It is likely that 
      other factors besides genes located on chromosome 21 may play a role in clinical 
      features of affected patients. Tumor necrosis factor-alpha (TNF-alpha) (6p21.3) 
      and apolipoprotein E (APOE) (19q13.2) are candidate genes as they interact with 
      the brain deposition of Abeta, one of the neuropathological hallmarks in DS. We 
      examined 136 DS patients and 113 controls for -850 TNF-alpha and APOE 
      polymorphisms. The -850T frequency in DS was significantly higher than in 
      controls (P<0.005, OR 2.05, 95% CI 1.22-3.49) while the APOE E4 allele was 
      negatively selected in patients compared to normal subjects (P<0.005, OR 0.38, 
      95% CI 0.20-0.71). Our findings suggest that the -850T allele, which is more 
      common among patients at high risk of dementia such as those with DS, might 
      eventually play a role in the development of dementia; no inference on the role 
      of the allele APOE E4 in DS-related dementia may be derived from our results.
FAU - Lucarelli, Paola
AU  - Lucarelli P
AD  - Institute of Molecular Biology and Pathology, National Research Council, Rome, 
      00185 Rome, Italy.
FAU - Piciullo, Antonella
AU  - Piciullo A
FAU - Verdecchia, Magda
AU  - Verdecchia M
FAU - Palmarino, Mariella
AU  - Palmarino M
FAU - Arpino, Carla
AU  - Arpino C
FAU - Curatolo, Paolo
AU  - Curatolo P
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Apolipoproteins E)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Apolipoproteins E/*genetics
MH  - Chi-Square Distribution
MH  - Child
MH  - Child, Preschool
MH  - Confidence Intervals
MH  - Dementia/complications/*genetics
MH  - Down Syndrome/complications/*genetics
MH  - Female
MH  - Gene Frequency/genetics
MH  - Genotype
MH  - Humans
MH  - Infant
MH  - Male
MH  - Odds Ratio
MH  - Polymorphism, Genetic/*genetics
MH  - Tumor Necrosis Factor-alpha/*genetics
EDAT- 2003/11/15 05:00
MHDA- 2004/01/21 05:00
CRDT- 2003/11/15 05:00
PHST- 2003/11/15 05:00 [pubmed]
PHST- 2004/01/21 05:00 [medline]
PHST- 2003/11/15 05:00 [entrez]
AID - S0304394003010061 [pii]
AID - 10.1016/j.neulet.2003.08.021 [doi]
PST - ppublish
SO  - Neurosci Lett. 2003 Nov 27;352(1):29-32. doi: 10.1016/j.neulet.2003.08.021.