PMID- 14615047 OWN - NLM STAT- MEDLINE DCOM- 20040120 LR - 20190701 IS - 0304-3940 (Print) IS - 0304-3940 (Linking) VI - 352 IP - 1 DP - 2003 Nov 27 TI - Immunoreactivity of brain-derived neurotrophic factor in rat dorsal root ganglion and spinal cord dorsal horn following exposure to herniated nucleus pulposus. PG - 49-52 AB - The pain mechanisms underlying radiculopathy due to disc herniation are still incompletely understood. This study assessed changes in brain-derived neurotrophic factor (BDNF) expression, a modulator of nociceptive information, in the dorsal root ganglion (DRG) and spinal cord dorsal horn following experimental disc herniation. Immunohistochemical analysis revealed an increase in percentage of BDNF-immunoreactive (IR) neurons profiles in the affected DRG and marked elevation in the BDNF-IR regions within both the superficial and deep layers at the corresponding spinal level with a peak at 3 days after nucleus pulposus (NP) application. These results thus show that herniated NP increases the BDNF production in the pain-processing neurons. Such changes can contribute to the development of inflammatory hyperalgesia. FAU - Onda, Akira AU - Onda A AD - Department of Orthopaedics, Sahlgrenska University Hospital, Goteborg University, SE-413 45 Gothenburg, Sweden. FAU - Murata, Yasuaki AU - Murata Y FAU - Rydevik, Bjorn AU - Rydevik B FAU - Larsson, Karin AU - Larsson K FAU - Kikuchi, Shinichi AU - Kikuchi S FAU - Olmarker, Kjell AU - Olmarker K LA - eng PT - Comparative Study PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - Ireland TA - Neurosci Lett JT - Neuroscience letters JID - 7600130 RN - 0 (Brain-Derived Neurotrophic Factor) SB - IM MH - Animals MH - Brain-Derived Neurotrophic Factor/analysis/*biosynthesis MH - Female MH - Ganglia, Spinal/chemistry/*metabolism MH - Immunochemistry MH - Intervertebral Disc Displacement/*metabolism MH - Posterior Horn Cells/chemistry/*metabolism MH - Rats MH - Rats, Sprague-Dawley EDAT- 2003/11/15 05:00 MHDA- 2004/01/21 05:00 CRDT- 2003/11/15 05:00 PHST- 2003/11/15 05:00 [pubmed] PHST- 2004/01/21 05:00 [medline] PHST- 2003/11/15 05:00 [entrez] AID - S0304394003010103 [pii] AID - 10.1016/j.neulet.2003.08.025 [doi] PST - ppublish SO - Neurosci Lett. 2003 Nov 27;352(1):49-52. doi: 10.1016/j.neulet.2003.08.025.