PMID- 14616253
OWN - NLM
STAT- MEDLINE
DCOM- 20040105
LR  - 20190815
IS  - 0001-6349 (Print)
IS  - 0001-6349 (Linking)
VI  - 82
IP  - 12
DP  - 2003 Dec
TI  - Inflammatory cytokines in intrauterine growth retardation.
PG  - 1099-102
AB  - BACKGROUND: To evaluate maternal serum levels of two inflammatory cytokines in 
      women with intrauterine growth retardation (IUGR), while studying separately 
      women with or without placental insufficiency. METHODS: The study comprised 14 
      women with IUGR and Doppler-defined placental insufficiency, 14 women with IUGR 
      without placental insufficiency, and 28 healthy pregnant women as a control 
      group. Tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) were 
      measured using a commercially available kit. The Kruskal-Wallis test and the 
      corrected Mann-Whitney U-test were used. RESULTS: There was a statistically 
      significant difference in TNF-alpha levels among the three studied groups (p = 
      0.03). Women with IUGR and placental insufficiency showed statistically 
      significant higher serum levels of TNF-alpha[2.2 pg/mL (1.3-4.1)] and a higher 
      rate of detectable TNF-alpha[85.7% (12/14)] than those in the control group [0 
      pg/mL (0-2.7) and 32.1% (9/28)] (p = 0.01 and p = 0.001, respectively). On the 
      contrary, there was no difference in either the TNF-alpha level [1.4 pg/mL 
      (0-4.9)] or the rate of detectable TNF-alpha[57.1% (8/14)] between women with 
      IUGR without placental insufficiency and women in the control group. The levels 
      of IL-6 were similar in the three studied groups. CONCLUSION: TNF-alpha is 
      increased in women with IUGR and placental insufficiency but normal in those with 
      IUGR and normal placental perfusion. We suggest that elevations of TNF-alpha 
      could be a specific phenomenon of certain subsets of IUGR, identifying cases with 
      placental dysfunction.
FAU - Bartha, Jose L
AU  - Bartha JL
AD  - Department of Obstetrics and Gynecology, University Hospital of Puerto Real, 
      Puerto Real, Cadiz, Spain. J.Bartha@bristol.ac.uk
FAU - Romero-Carmona, Raquel
AU  - Romero-Carmona R
FAU - Comino-Delgado, Rafael
AU  - Comino-Delgado R
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Acta Obstet Gynecol Scand
JT  - Acta obstetricia et gynecologica Scandinavica
JID - 0370343
RN  - 0 (Biomarkers)
RN  - 0 (Cytokines)
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Biomarkers/analysis
MH  - Case-Control Studies
MH  - Cytokines/analysis
MH  - Female
MH  - Fetal Growth Retardation/*diagnosis/diagnostic imaging
MH  - Humans
MH  - Interleukin-6/*analysis
MH  - Placental Insufficiency/diagnosis/*diagnostic imaging
MH  - Pregnancy
MH  - *Pregnancy Outcome
MH  - Prenatal Care
MH  - Probability
MH  - Prospective Studies
MH  - Reference Values
MH  - Sensitivity and Specificity
MH  - Statistics, Nonparametric
MH  - Tumor Necrosis Factor-alpha/*analysis
MH  - Ultrasonography, Doppler
MH  - *Ultrasonography, Prenatal
EDAT- 2003/11/18 05:00
MHDA- 2004/01/06 05:00
CRDT- 2003/11/18 05:00
PHST- 2003/11/18 05:00 [pubmed]
PHST- 2004/01/06 05:00 [medline]
PHST- 2003/11/18 05:00 [entrez]
AID - 259 [pii]
AID - 10.1046/j.1600-0412.2003.00259.x [doi]
PST - ppublish
SO  - Acta Obstet Gynecol Scand. 2003 Dec;82(12):1099-102. doi: 
      10.1046/j.1600-0412.2003.00259.x.