PMID- 14616961
OWN - NLM
STAT- MEDLINE
DCOM- 20040105
LR  - 20190705
IS  - 0007-1048 (Print)
IS  - 0007-1048 (Linking)
VI  - 123
IP  - 4
DP  - 2003 Nov
TI  - Mutual exclusion of t(11;18)(q21;q21) and numerical chromosomal aberrations in 
      the development of different types of primary gastric lymphomas.
PG  - 590-9
AB  - Gastric non-Hodgkin's lymphomas can be divided histologically into 
      mucosa-associated lymphoid tissue (MALT) lymphoma (ML) and diffuse large cell 
      lymphoma (DLCL) with or without evidence of preceding/accompanying ML (DLCL + 
      ML). We studied the incidence of the most frequent structural chromosomal 
      aberration in ML, t(11;18)(q21;q21), and numerical aberrations of seven 
      chromosomes in 36 ML, 39 DLCL + ML and ten gastric DLCL cases, by dual-colour 
      interphase fluorescence in situ hybridization (FISH) and reverse transcriptase 
      polymerase chain reaction (RT-PCR). t(11;18)(q21;q21) was exclusively detected in 
      ML (FISH 22%; RT-PCR 24%), being completely absent in DLCL + ML and DLCL. No 
      other translocations involving 11q21 or 18q21 and other partner chromosomes were 
      detected by FISH. In lymphomas harbouring t(11;18)(q21;q21), this translocation 
      was the sole genetic abnormality. In contrast, 45% of the 
      t(11;18)(q21;q21)-negative ML showed trisomies, especially of chromosome 3 and 
      18. In DLCL + ML with separate small and large cell components, trisomies were 
      either detected in both components or occurred exclusively in large tumour cells. 
      Our results suggest that ML can be divided in lymphomas characterized by the 
      t(11;18)(q21;q21), which are unlikely to transform into high-grade tumours, and 
      t(11;18)(q21;q21)-negative ML that may develop into DLCL + ML after the 
      acquisition of additional genetic aberrations.
FAU - Schreuder, Max I
AU  - Schreuder MI
AD  - Department of Pathology, University Medical Centre Nijmegen, Nijmegen, The 
      Netherlands. m.schreuder@pathol.umcn.nl
FAU - Hoeve, Marieke A
AU  - Hoeve MA
FAU - Hebeda, Konnie M
AU  - Hebeda KM
FAU - Verdijk, Marian A
AU  - Verdijk MA
FAU - Ligtenberg, Marjolijn J
AU  - Ligtenberg MJ
FAU - Bot, Frederik J
AU  - Bot FJ
FAU - Chott, Andreas
AU  - Chott A
FAU - van Krieken, J Han J M
AU  - van Krieken JH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Br J Haematol
JT  - British journal of haematology
JID - 0372544
SB  - IM
MH  - *Chromosomes, Human, Pair 11
MH  - *Chromosomes, Human, Pair 18
MH  - Chromosomes, Human, Pair 3
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Incidence
MH  - Lymphoma, B-Cell, Marginal Zone/genetics
MH  - Lymphoma, Non-Hodgkin/*genetics
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Stomach Neoplasms/genetics
MH  - *Translocation, Genetic
MH  - Trisomy
EDAT- 2003/11/18 05:00
MHDA- 2004/01/06 05:00
CRDT- 2003/11/18 05:00
PHST- 2003/11/18 05:00 [pubmed]
PHST- 2004/01/06 05:00 [medline]
PHST- 2003/11/18 05:00 [entrez]
AID - 4630 [pii]
AID - 10.1046/j.1365-2141.2003.04630.x [doi]
PST - ppublish
SO  - Br J Haematol. 2003 Nov;123(4):590-9. doi: 10.1046/j.1365-2141.2003.04630.x.